FTY720 prevents ischemia/reperfusion injury-associated arrhythmias in an ex vivo rat heart model via activation of Pak1/Akt signaling.

FTY720 prevents ischemia/reperfusion injury-associated arrhythmias in an ex vivo rat heart model via activation of Pak1/Akt signaling.

Recent studies demonstrated a role of sphingosine-1-phosphate (S1P) in the protection against the stress of ischemia/reperfusion (I/R) injury. In experiments reported here, we have investigated the signaling through the S1P cascade by FTY720, a sphingolipid drug candidate displaying structural simil...

Full description

Bibliographic Details
Main Authors:	Egom, E, Ke, Y, Musa, H, Mohamed, T, Wang, T, Cartwright, E, Solaro, R, Lei, M
Format:	Journal article
Language:	English
Published:	2010

Similar Items

The antineoplastic properties of FTY720: Evidence for the repurposing of fingolimod
by: Patmanathan, S.N., et al.
Published: (2015)

Effect of FTY720P on lipid accumulation in HEPG2 cells
by: Reem Rida, et al.
Published: (2023-11-01)

The protective role of FTY720 in promoting survival of allograft fat in mice
by: Yi Yi, et al.
Published: (2022-09-01)

Anti-tumor drug FTY720 regulates p53-dependent transcription
by: YAO Han, XU Wen-bin, WANG Dong-lai
Published: (2021-03-01)

FTY720 in immuno-regenerative and wound healing technologies for muscle, epithelial and bone regeneration
by: Monica Behara, et al.
Published: (2023-05-01)

FTY720/fingolimod, a sphingosine analogue, reduces amyloid-β production in neurons.
by: Nobumasa Takasugi, et al.
Published: (2013-01-01)

Altered Expression of Signaling Genes in Jurkat Cells upon FTY720 Induced Apoptosis
by: Shaoheng He, et al.
Published: (2010-09-01)

In Vivo micro-PET Imaging Demonstrates Diminished Microglial Activation after FTY720 Treatment in an Animal Model of Multiple Sclerosis
by: Airas, L, et al.
Published: (2013)

Correction: Disparate In Vivo Efficacy of FTY720 in Xenograft Models of Philadelphia Positive and Negative B-lineage Acute Lymphoblastic Leukemia
Published: (2012-01-01)

Effects of FTY720 on brain neurogenic niches in vitro and after kainic acid-induced injury
by: Raffaela Cipriani, et al.
Published: (2017-07-01)

Fingolimod (FTY720) Preserves High Energy Phosphates and Improves Cardiac Function in Heterotopic Heart Transplantation Model
by: Naseer Ahmed, et al.
Published: (2020-09-01)

The Effects of the S1P Receptor Agonist Fingolimod (FTY720) on Central and Peripheral Myelin in Twitcher Mice
by: Sibylle Béchet, et al.
Published: (2024-03-01)

FTY720 Inhibits Expansion of Breast Cancer Stem Cells via PP2A Activation
by: Naoya Hirata, et al.
Published: (2021-07-01)

Fingolimod (FTY720) Tedavisinin Relapsing-Remitting Multipl Skleroz Hastalarında Karaciğer Enzim Düzeylerine Etkisi
by: Duygu Tap, et al.
Published: (2020-12-01)

FTY720 increases sensitivity of Temozolomid due to down-regulation of N-Cadherin expression in glioblastoma cells
by: Malgorzata Kolodziej
Published: (2023-01-01)

Signaling Cascade Mediating the Effect of FTY720P on the Na+/K+ ATPase in LLC-PK1
by: Christine Khalil, et al.
Published: (2022-08-01)

An ex vivo model to investigate human vascular ischemia-reperfusion injury
by: Juul-Dam, K, et al.
Published: (2009)

Changes in lymphocyte phenotype and increased skin allograft survival after FTY720+FK506 therapy Modificação do fenótipo linfocitário e aumento da sobrevida do enxerto de pele após a terapia com FTY720 + FK506
by: Camila T. Lopes, et al.
Published: (2008-01-01)

Anti-Inflammatory Treatment with FTY720 Starting after Onset of Symptoms Reverses Synaptic Deficits in an AD Mouse Model
by: Georgia-Ioanna Kartalou, et al.
Published: (2020-11-01)

S1P1 Threonine 236 Phosphorylation Mediates the Invasiveness of Triple-Negative Breast Cancer and Sensitivity to FTY720
by: Fabrice J. F. Laroche, et al.
Published: (2023-03-01)

Ameliorative effects of Fingolimod (FTY720) on microglial activation and psychosis-related behavior in short term cuprizone exposed mice
by: Siyao Li, et al.
Published: (2023-07-01)

FTY720 induces apoptosis in B16F10-NEX2 murine melanoma cells, limits metastatic development in vivo, and modulates the immune system
by: Felipe V. Pereira, et al.
Published: (2013-07-01)

Differential Expression of the Sphingolipid Pathway Is Associated with Sensitivity to the PP2A Activator FTY720 in Colorectal Cancer Cell Lines
by: Peter Sciberras, et al.
Published: (2021-10-01)

Fingolimod (FTY720), a Sphinogosine-1-Phosphate Receptor Agonist, Mitigates Choroidal Endothelial Proangiogenic Properties and Choroidal Neovascularization
by: Christine M. Sorenson, et al.
Published: (2022-03-01)

Immunomodulatory drug fingolimod (FTY720) restricts the growth of opportunistic yeast Candida albicans in vitro and in a mouse candidiasis model
by: Niloofar Najarzadegan, et al.
Published: (2022-01-01)

Immunomodulatory drug fingolimod (FTY720) restricts the growth of opportunistic yeast Candida albicans in vitro and in a mouse candidiasis model.
by: Niloofar Najarzadegan, et al.
Published: (2022-01-01)

In Vitro/Ex Vivo Models for the Study of Ischemia Reperfusion Injury during Kidney Perfusion
by: Sebastien Giraud, et al.
Published: (2020-10-01)

Complement-targeting therapeutics for ischemia-reperfusion injury in transplantation and the potential for ex vivo delivery
by: Isabel F. Delaura, et al.
Published: (2022-10-01)

Induction of Lysosomal Membrane Permeabilization Is a Major Event of FTY720-Mediated Non-Apoptotic Cell Death in Human Glioma Cells
by: Kyoung-jin Min, et al.
Published: (2020-11-01)

FTY720-P, a Biased S1PR Ligand, Increases Mitochondrial Function through STAT3 Activation in Cardiac Cells
by: Juan Pablo Muñoz, et al.
Published: (2023-04-01)

FTY720 Reduces Lipid Accumulation by Upregulating ABCA1 through Liver X Receptor and Sphingosine Kinase 2 Signaling in Macrophages
by: Koki Tachibana, et al.
Published: (2022-11-01)

FTY720 decreases ceramides levels in the brain and prevents memory impairments in a mouse model of familial Alzheimer’s disease expressing APOE4
by: Simone M. Crivelli, et al.
Published: (2022-08-01)

PAK1 contributes to cerebral ischemia/reperfusion injury by regulating the blood-brain barrier integrity
by: Ming Huang, et al.
Published: (2023-08-01)

Ex Vivo Lung Perfusion with K(ATP) Channel Modulators Antagonize Ischemia Reperfusion Injury
by: Stephan Arni, et al.
Published: (2021-09-01)

FTY720 requires vitamin B12-TCN2-CD320 signaling in astrocytes to reduce disease in an animal model of multiple sclerosis
by: Deepa Jonnalagadda, et al.
Published: (2023-12-01)

FTY720 Attenuates LPS-Induced Inflammatory Bone Loss by Inhibiting Osteoclastogenesis via the NF-κB and HDAC4/ATF Pathways
by: Chongwei Chen, et al.
Published: (2023-01-01)

Akt: A Therapeutic Target in Hepatic Ischemia–Reperfusion Injury
by: Stephen M. Covington, et al.
Published: (2017-01-01)

Sarcospan Deficiency Increases Oxidative Stress and Arrhythmias in Hearts after Acute Ischemia-Reperfusion Injury
by: Hyun Seok Hwang, et al.
Published: (2023-07-01)

FTY720/fingolimod increases NPC1 and NPC2 expression and reduces cholesterol and sphingolipid accumulation in Niemann-Pick type C mutant fibroblasts
by: Newton, J, et al.
Published: (2017)

Presynaptic Release-Regulating Sphingosine 1-Phosphate 1/3 Receptors in Cortical Glutamatergic Terminals: Adaptations in EAE Mice and Impact of Therapeutic FTY720
by: Alessandra Roggeri, et al.
Published: (2023-09-01)