Generation of novel human MHC class II mutant B-cell lines by integrating YAC DNA into a cell line homozygously deleted for the MHC class II region.

Generation of novel human MHC class II mutant B-cell lines by integrating YAC DNA into a cell line homozygously deleted for the MHC class II region.

The human B lymphoblastoid cell line (LCL) 721.174 sustains a large homozygous deletion in the major histocompatibility complex (MHC) class II region that results in an absence of DQ and DR molecules as well as a deficiency in the assembly and transport of class I molecules to the cell surface. The...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser:	Fabb, SA, Davies, A, Correa, I, Kelly, A, Mackie, C, Trowsdale, J, Ragoussis, I
Format:	Journal article
Sprache:	English
Veröffentlicht:	1997

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