Mucosal immunology: IgA production requires B cell interaction with subepithelial dendritic cells in Peyer's patches
Immunoglobulin A (IgA) induction primarily occurs in intestinal Peyer's patches (PPs). However, the cellular interactions necessary for IgA class switching are poorly defined. Here we show that in mice, activated B cells use the chemokine receptor CCR6 to access the subepithelial dome (SED) of...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
American Association for the Advancement of Science
2016
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| _version_ | 1797075615553159168 |
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| author | Reboldi, A Arnon, T Rodda, L Atakilit, A Sheppard, D Cyster, J |
| author_facet | Reboldi, A Arnon, T Rodda, L Atakilit, A Sheppard, D Cyster, J |
| author_sort | Reboldi, A |
| collection | OXFORD |
| description | Immunoglobulin A (IgA) induction primarily occurs in intestinal Peyer's patches (PPs). However, the cellular interactions necessary for IgA class switching are poorly defined. Here we show that in mice, activated B cells use the chemokine receptor CCR6 to access the subepithelial dome (SED) of PPs. There, B cells undergo prolonged interactions with SED dendritic cells (DCs). PP IgA class switching requires innate lymphoid cells, which promote lymphotoxin-β receptor (LTβR)-dependent maintenance of DCs. PP DCs augment IgA production by integrin avb8-mediated activation of transforming growth factor-β (TGFβ). In mice where B cells cannot access the SED, IgA responses against oral antigen and gut commensals are impaired. These studies establish the PP SED as a niche supporting DC-B cell interactions needed for TGFβ activation and induction of mucosal IgA responses. |
| first_indexed | 2024-03-06T23:52:49Z |
| format | Journal article |
| id | oxford-uuid:7332f488-9b07-4a2a-ba5d-edf5bed0be16 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:52:49Z |
| publishDate | 2016 |
| publisher | American Association for the Advancement of Science |
| record_format | dspace |
| spelling | oxford-uuid:7332f488-9b07-4a2a-ba5d-edf5bed0be162022-03-26T19:54:49ZMucosal immunology: IgA production requires B cell interaction with subepithelial dendritic cells in Peyer's patchesJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:7332f488-9b07-4a2a-ba5d-edf5bed0be16EnglishSymplectic Elements at OxfordAmerican Association for the Advancement of Science2016Reboldi, AArnon, TRodda, LAtakilit, ASheppard, DCyster, JImmunoglobulin A (IgA) induction primarily occurs in intestinal Peyer's patches (PPs). However, the cellular interactions necessary for IgA class switching are poorly defined. Here we show that in mice, activated B cells use the chemokine receptor CCR6 to access the subepithelial dome (SED) of PPs. There, B cells undergo prolonged interactions with SED dendritic cells (DCs). PP IgA class switching requires innate lymphoid cells, which promote lymphotoxin-β receptor (LTβR)-dependent maintenance of DCs. PP DCs augment IgA production by integrin avb8-mediated activation of transforming growth factor-β (TGFβ). In mice where B cells cannot access the SED, IgA responses against oral antigen and gut commensals are impaired. These studies establish the PP SED as a niche supporting DC-B cell interactions needed for TGFβ activation and induction of mucosal IgA responses. |
| spellingShingle | Reboldi, A Arnon, T Rodda, L Atakilit, A Sheppard, D Cyster, J Mucosal immunology: IgA production requires B cell interaction with subepithelial dendritic cells in Peyer's patches |
| title | Mucosal immunology: IgA production requires B cell interaction with subepithelial dendritic cells in Peyer's patches |
| title_full | Mucosal immunology: IgA production requires B cell interaction with subepithelial dendritic cells in Peyer's patches |
| title_fullStr | Mucosal immunology: IgA production requires B cell interaction with subepithelial dendritic cells in Peyer's patches |
| title_full_unstemmed | Mucosal immunology: IgA production requires B cell interaction with subepithelial dendritic cells in Peyer's patches |
| title_short | Mucosal immunology: IgA production requires B cell interaction with subepithelial dendritic cells in Peyer's patches |
| title_sort | mucosal immunology iga production requires b cell interaction with subepithelial dendritic cells in peyer s patches |
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