Ovarian cancer risk factors by histologic subtype: an analysis from the Ovarian Cancer Cohort Consortium
An understanding of the etiologic heterogeneity of ovarian cancer is important for improving prevention, early detection, and therapeutic approaches. We evaluated 14 hormonal, reproductive, and lifestyle factors by histologic subtype in the Ovarian Cancer Cohort Consortium (OC3).Among 1.3 million wo...
| Κύριοι συγγραφείς: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Μορφή: | Journal article |
| Γλώσσα: | English |
| Έκδοση: |
American Society of Clinical Oncology
2016
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| _version_ | 1826279065762398208 |
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| author | Wentzensen, N Poole, E Trabert, B White, E Arslan, A Patel, A Setiawan, V Visvanathan, K Weiderpass, E Adami, H Black, A Bernstein, L Brinton, L Buring, J Butler, L Chamosa, S Clendenen, T Dossus, L Fortner, R Gapstur, S Gaudet, M Gram, I Hartge, P Hoffman-Bolton, J Idahl, A Jones, M Kaaks, R Kirsh, V Koh, W Lacey, J Lee, I Lundin, E Merritt, M Onland-Moret, N Peters, U Poynter, J Rinaldi, S Robien, K Rohan, T Sandler, D Schairer, C Schouten, L Sjöholm, L Sieri, S Swerdlow, A Tjonneland, A Travis, R Trichopoulou, A van den Brandt, P Wilkens, L Wolk, A Yang, H Zeleniuch-Jacquotte, A Tworoger, S |
| author_facet | Wentzensen, N Poole, E Trabert, B White, E Arslan, A Patel, A Setiawan, V Visvanathan, K Weiderpass, E Adami, H Black, A Bernstein, L Brinton, L Buring, J Butler, L Chamosa, S Clendenen, T Dossus, L Fortner, R Gapstur, S Gaudet, M Gram, I Hartge, P Hoffman-Bolton, J Idahl, A Jones, M Kaaks, R Kirsh, V Koh, W Lacey, J Lee, I Lundin, E Merritt, M Onland-Moret, N Peters, U Poynter, J Rinaldi, S Robien, K Rohan, T Sandler, D Schairer, C Schouten, L Sjöholm, L Sieri, S Swerdlow, A Tjonneland, A Travis, R Trichopoulou, A van den Brandt, P Wilkens, L Wolk, A Yang, H Zeleniuch-Jacquotte, A Tworoger, S |
| author_sort | Wentzensen, N |
| collection | OXFORD |
| description | An understanding of the etiologic heterogeneity of ovarian cancer is important for improving prevention, early detection, and therapeutic approaches. We evaluated 14 hormonal, reproductive, and lifestyle factors by histologic subtype in the Ovarian Cancer Cohort Consortium (OC3).Among 1.3 million women from 21 studies, 5,584 invasive epithelial ovarian cancers were identified (3,378 serous, 606 endometrioid, 331 mucinous, 269 clear cell, 1,000 other). By using competing-risks Cox proportional hazards regression stratified by study and birth year and adjusted for age, parity, and oral contraceptive use, we assessed associations for all invasive cancers by histology. Heterogeneity was evaluated by likelihood ratio test.Most risk factors exhibited significant heterogeneity by histology. Higher parity was most strongly associated with endometrioid (relative risk [RR] per birth, 0.78; 95% CI, 0.74 to 0.83) and clear cell (RR, 0.68; 95% CI, 0.61 to 0.76) carcinomas (P value for heterogeneity [P-het] < .001). Similarly, age at menopause, endometriosis, and tubal ligation were only associated with endometrioid and clear cell tumors (P-het ≤ .01). Family history of breast cancer (P-het = .008) had modest heterogeneity. Smoking was associated with an increased risk of mucinous (RR per 20 pack-years, 1.26; 95% CI, 1.08 to 1.46) but a decreased risk of clear cell (RR, 0.72; 95% CI, 0.55 to 0.94) tumors (P-het = .004). Unsupervised clustering by risk factors separated endometrioid, clear cell, and low-grade serous carcinomas from high-grade serous and mucinous carcinomas.The heterogeneous associations of risk factors with ovarian cancer subtypes emphasize the importance of conducting etiologic studies by ovarian cancer subtypes. Most established risk factors were more strongly associated with nonserous carcinomas, which demonstrate challenges for risk prediction of serous cancers, the most fatal subtype. |
| first_indexed | 2024-03-06T23:53:16Z |
| format | Journal article |
| id | oxford-uuid:7357dbdb-d3a3-4951-a654-1c4170e9c4ad |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:53:16Z |
| publishDate | 2016 |
| publisher | American Society of Clinical Oncology |
| record_format | dspace |
| spelling | oxford-uuid:7357dbdb-d3a3-4951-a654-1c4170e9c4ad2022-03-26T19:56:07ZOvarian cancer risk factors by histologic subtype: an analysis from the Ovarian Cancer Cohort ConsortiumJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:7357dbdb-d3a3-4951-a654-1c4170e9c4adEnglishSymplectic Elements at OxfordAmerican Society of Clinical Oncology2016Wentzensen, NPoole, ETrabert, BWhite, EArslan, APatel, ASetiawan, VVisvanathan, KWeiderpass, EAdami, HBlack, ABernstein, LBrinton, LBuring, JButler, LChamosa, SClendenen, TDossus, LFortner, RGapstur, SGaudet, MGram, IHartge, PHoffman-Bolton, JIdahl, AJones, MKaaks, RKirsh, VKoh, WLacey, JLee, ILundin, EMerritt, MOnland-Moret, NPeters, UPoynter, JRinaldi, SRobien, KRohan, TSandler, DSchairer, CSchouten, LSjöholm, LSieri, SSwerdlow, ATjonneland, ATravis, RTrichopoulou, Avan den Brandt, PWilkens, LWolk, AYang, HZeleniuch-Jacquotte, ATworoger, SAn understanding of the etiologic heterogeneity of ovarian cancer is important for improving prevention, early detection, and therapeutic approaches. We evaluated 14 hormonal, reproductive, and lifestyle factors by histologic subtype in the Ovarian Cancer Cohort Consortium (OC3).Among 1.3 million women from 21 studies, 5,584 invasive epithelial ovarian cancers were identified (3,378 serous, 606 endometrioid, 331 mucinous, 269 clear cell, 1,000 other). By using competing-risks Cox proportional hazards regression stratified by study and birth year and adjusted for age, parity, and oral contraceptive use, we assessed associations for all invasive cancers by histology. Heterogeneity was evaluated by likelihood ratio test.Most risk factors exhibited significant heterogeneity by histology. Higher parity was most strongly associated with endometrioid (relative risk [RR] per birth, 0.78; 95% CI, 0.74 to 0.83) and clear cell (RR, 0.68; 95% CI, 0.61 to 0.76) carcinomas (P value for heterogeneity [P-het] < .001). Similarly, age at menopause, endometriosis, and tubal ligation were only associated with endometrioid and clear cell tumors (P-het ≤ .01). Family history of breast cancer (P-het = .008) had modest heterogeneity. Smoking was associated with an increased risk of mucinous (RR per 20 pack-years, 1.26; 95% CI, 1.08 to 1.46) but a decreased risk of clear cell (RR, 0.72; 95% CI, 0.55 to 0.94) tumors (P-het = .004). Unsupervised clustering by risk factors separated endometrioid, clear cell, and low-grade serous carcinomas from high-grade serous and mucinous carcinomas.The heterogeneous associations of risk factors with ovarian cancer subtypes emphasize the importance of conducting etiologic studies by ovarian cancer subtypes. Most established risk factors were more strongly associated with nonserous carcinomas, which demonstrate challenges for risk prediction of serous cancers, the most fatal subtype. |
| spellingShingle | Wentzensen, N Poole, E Trabert, B White, E Arslan, A Patel, A Setiawan, V Visvanathan, K Weiderpass, E Adami, H Black, A Bernstein, L Brinton, L Buring, J Butler, L Chamosa, S Clendenen, T Dossus, L Fortner, R Gapstur, S Gaudet, M Gram, I Hartge, P Hoffman-Bolton, J Idahl, A Jones, M Kaaks, R Kirsh, V Koh, W Lacey, J Lee, I Lundin, E Merritt, M Onland-Moret, N Peters, U Poynter, J Rinaldi, S Robien, K Rohan, T Sandler, D Schairer, C Schouten, L Sjöholm, L Sieri, S Swerdlow, A Tjonneland, A Travis, R Trichopoulou, A van den Brandt, P Wilkens, L Wolk, A Yang, H Zeleniuch-Jacquotte, A Tworoger, S Ovarian cancer risk factors by histologic subtype: an analysis from the Ovarian Cancer Cohort Consortium |
| title | Ovarian cancer risk factors by histologic subtype: an analysis from the Ovarian Cancer Cohort Consortium |
| title_full | Ovarian cancer risk factors by histologic subtype: an analysis from the Ovarian Cancer Cohort Consortium |
| title_fullStr | Ovarian cancer risk factors by histologic subtype: an analysis from the Ovarian Cancer Cohort Consortium |
| title_full_unstemmed | Ovarian cancer risk factors by histologic subtype: an analysis from the Ovarian Cancer Cohort Consortium |
| title_short | Ovarian cancer risk factors by histologic subtype: an analysis from the Ovarian Cancer Cohort Consortium |
| title_sort | ovarian cancer risk factors by histologic subtype an analysis from the ovarian cancer cohort consortium |
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