Ovarian cancer risk factors by histologic subtype: an analysis from the Ovarian Cancer Cohort Consortium
An understanding of the etiologic heterogeneity of ovarian cancer is important for improving prevention, early detection, and therapeutic approaches. We evaluated 14 hormonal, reproductive, and lifestyle factors by histologic subtype in the Ovarian Cancer Cohort Consortium (OC3).Among 1.3 million wo...
| Hlavní autoři: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Médium: | Journal article |
| Jazyk: | English |
| Vydáno: |
American Society of Clinical Oncology
2016
|
| _version_ | 1826279065762398208 |
|---|---|
| author | Wentzensen, N Poole, E Trabert, B White, E Arslan, A Patel, A Setiawan, V Visvanathan, K Weiderpass, E Adami, H Black, A Bernstein, L Brinton, L Buring, J Butler, L Chamosa, S Clendenen, T Dossus, L Fortner, R Gapstur, S Gaudet, M Gram, I Hartge, P Hoffman-Bolton, J Idahl, A Jones, M Kaaks, R Kirsh, V Koh, W Lacey, J Lee, I Lundin, E Merritt, M Onland-Moret, N Peters, U Poynter, J Rinaldi, S Robien, K Rohan, T Sandler, D Schairer, C Schouten, L Sjöholm, L Sieri, S Swerdlow, A Tjonneland, A Travis, R Trichopoulou, A van den Brandt, P Wilkens, L Wolk, A Yang, H Zeleniuch-Jacquotte, A Tworoger, S |
| author_facet | Wentzensen, N Poole, E Trabert, B White, E Arslan, A Patel, A Setiawan, V Visvanathan, K Weiderpass, E Adami, H Black, A Bernstein, L Brinton, L Buring, J Butler, L Chamosa, S Clendenen, T Dossus, L Fortner, R Gapstur, S Gaudet, M Gram, I Hartge, P Hoffman-Bolton, J Idahl, A Jones, M Kaaks, R Kirsh, V Koh, W Lacey, J Lee, I Lundin, E Merritt, M Onland-Moret, N Peters, U Poynter, J Rinaldi, S Robien, K Rohan, T Sandler, D Schairer, C Schouten, L Sjöholm, L Sieri, S Swerdlow, A Tjonneland, A Travis, R Trichopoulou, A van den Brandt, P Wilkens, L Wolk, A Yang, H Zeleniuch-Jacquotte, A Tworoger, S |
| author_sort | Wentzensen, N |
| collection | OXFORD |
| description | An understanding of the etiologic heterogeneity of ovarian cancer is important for improving prevention, early detection, and therapeutic approaches. We evaluated 14 hormonal, reproductive, and lifestyle factors by histologic subtype in the Ovarian Cancer Cohort Consortium (OC3).Among 1.3 million women from 21 studies, 5,584 invasive epithelial ovarian cancers were identified (3,378 serous, 606 endometrioid, 331 mucinous, 269 clear cell, 1,000 other). By using competing-risks Cox proportional hazards regression stratified by study and birth year and adjusted for age, parity, and oral contraceptive use, we assessed associations for all invasive cancers by histology. Heterogeneity was evaluated by likelihood ratio test.Most risk factors exhibited significant heterogeneity by histology. Higher parity was most strongly associated with endometrioid (relative risk [RR] per birth, 0.78; 95% CI, 0.74 to 0.83) and clear cell (RR, 0.68; 95% CI, 0.61 to 0.76) carcinomas (P value for heterogeneity [P-het] < .001). Similarly, age at menopause, endometriosis, and tubal ligation were only associated with endometrioid and clear cell tumors (P-het ≤ .01). Family history of breast cancer (P-het = .008) had modest heterogeneity. Smoking was associated with an increased risk of mucinous (RR per 20 pack-years, 1.26; 95% CI, 1.08 to 1.46) but a decreased risk of clear cell (RR, 0.72; 95% CI, 0.55 to 0.94) tumors (P-het = .004). Unsupervised clustering by risk factors separated endometrioid, clear cell, and low-grade serous carcinomas from high-grade serous and mucinous carcinomas.The heterogeneous associations of risk factors with ovarian cancer subtypes emphasize the importance of conducting etiologic studies by ovarian cancer subtypes. Most established risk factors were more strongly associated with nonserous carcinomas, which demonstrate challenges for risk prediction of serous cancers, the most fatal subtype. |
| first_indexed | 2024-03-06T23:53:16Z |
| format | Journal article |
| id | oxford-uuid:7357dbdb-d3a3-4951-a654-1c4170e9c4ad |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:53:16Z |
| publishDate | 2016 |
| publisher | American Society of Clinical Oncology |
| record_format | dspace |
| spelling | oxford-uuid:7357dbdb-d3a3-4951-a654-1c4170e9c4ad2022-03-26T19:56:07ZOvarian cancer risk factors by histologic subtype: an analysis from the Ovarian Cancer Cohort ConsortiumJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:7357dbdb-d3a3-4951-a654-1c4170e9c4adEnglishSymplectic Elements at OxfordAmerican Society of Clinical Oncology2016Wentzensen, NPoole, ETrabert, BWhite, EArslan, APatel, ASetiawan, VVisvanathan, KWeiderpass, EAdami, HBlack, ABernstein, LBrinton, LBuring, JButler, LChamosa, SClendenen, TDossus, LFortner, RGapstur, SGaudet, MGram, IHartge, PHoffman-Bolton, JIdahl, AJones, MKaaks, RKirsh, VKoh, WLacey, JLee, ILundin, EMerritt, MOnland-Moret, NPeters, UPoynter, JRinaldi, SRobien, KRohan, TSandler, DSchairer, CSchouten, LSjöholm, LSieri, SSwerdlow, ATjonneland, ATravis, RTrichopoulou, Avan den Brandt, PWilkens, LWolk, AYang, HZeleniuch-Jacquotte, ATworoger, SAn understanding of the etiologic heterogeneity of ovarian cancer is important for improving prevention, early detection, and therapeutic approaches. We evaluated 14 hormonal, reproductive, and lifestyle factors by histologic subtype in the Ovarian Cancer Cohort Consortium (OC3).Among 1.3 million women from 21 studies, 5,584 invasive epithelial ovarian cancers were identified (3,378 serous, 606 endometrioid, 331 mucinous, 269 clear cell, 1,000 other). By using competing-risks Cox proportional hazards regression stratified by study and birth year and adjusted for age, parity, and oral contraceptive use, we assessed associations for all invasive cancers by histology. Heterogeneity was evaluated by likelihood ratio test.Most risk factors exhibited significant heterogeneity by histology. Higher parity was most strongly associated with endometrioid (relative risk [RR] per birth, 0.78; 95% CI, 0.74 to 0.83) and clear cell (RR, 0.68; 95% CI, 0.61 to 0.76) carcinomas (P value for heterogeneity [P-het] < .001). Similarly, age at menopause, endometriosis, and tubal ligation were only associated with endometrioid and clear cell tumors (P-het ≤ .01). Family history of breast cancer (P-het = .008) had modest heterogeneity. Smoking was associated with an increased risk of mucinous (RR per 20 pack-years, 1.26; 95% CI, 1.08 to 1.46) but a decreased risk of clear cell (RR, 0.72; 95% CI, 0.55 to 0.94) tumors (P-het = .004). Unsupervised clustering by risk factors separated endometrioid, clear cell, and low-grade serous carcinomas from high-grade serous and mucinous carcinomas.The heterogeneous associations of risk factors with ovarian cancer subtypes emphasize the importance of conducting etiologic studies by ovarian cancer subtypes. Most established risk factors were more strongly associated with nonserous carcinomas, which demonstrate challenges for risk prediction of serous cancers, the most fatal subtype. |
| spellingShingle | Wentzensen, N Poole, E Trabert, B White, E Arslan, A Patel, A Setiawan, V Visvanathan, K Weiderpass, E Adami, H Black, A Bernstein, L Brinton, L Buring, J Butler, L Chamosa, S Clendenen, T Dossus, L Fortner, R Gapstur, S Gaudet, M Gram, I Hartge, P Hoffman-Bolton, J Idahl, A Jones, M Kaaks, R Kirsh, V Koh, W Lacey, J Lee, I Lundin, E Merritt, M Onland-Moret, N Peters, U Poynter, J Rinaldi, S Robien, K Rohan, T Sandler, D Schairer, C Schouten, L Sjöholm, L Sieri, S Swerdlow, A Tjonneland, A Travis, R Trichopoulou, A van den Brandt, P Wilkens, L Wolk, A Yang, H Zeleniuch-Jacquotte, A Tworoger, S Ovarian cancer risk factors by histologic subtype: an analysis from the Ovarian Cancer Cohort Consortium |
| title | Ovarian cancer risk factors by histologic subtype: an analysis from the Ovarian Cancer Cohort Consortium |
| title_full | Ovarian cancer risk factors by histologic subtype: an analysis from the Ovarian Cancer Cohort Consortium |
| title_fullStr | Ovarian cancer risk factors by histologic subtype: an analysis from the Ovarian Cancer Cohort Consortium |
| title_full_unstemmed | Ovarian cancer risk factors by histologic subtype: an analysis from the Ovarian Cancer Cohort Consortium |
| title_short | Ovarian cancer risk factors by histologic subtype: an analysis from the Ovarian Cancer Cohort Consortium |
| title_sort | ovarian cancer risk factors by histologic subtype an analysis from the ovarian cancer cohort consortium |
| work_keys_str_mv | AT wentzensenn ovariancancerriskfactorsbyhistologicsubtypeananalysisfromtheovariancancercohortconsortium AT poolee ovariancancerriskfactorsbyhistologicsubtypeananalysisfromtheovariancancercohortconsortium AT trabertb ovariancancerriskfactorsbyhistologicsubtypeananalysisfromtheovariancancercohortconsortium AT whitee ovariancancerriskfactorsbyhistologicsubtypeananalysisfromtheovariancancercohortconsortium AT arslana ovariancancerriskfactorsbyhistologicsubtypeananalysisfromtheovariancancercohortconsortium AT patela ovariancancerriskfactorsbyhistologicsubtypeananalysisfromtheovariancancercohortconsortium AT setiawanv ovariancancerriskfactorsbyhistologicsubtypeananalysisfromtheovariancancercohortconsortium AT visvanathank ovariancancerriskfactorsbyhistologicsubtypeananalysisfromtheovariancancercohortconsortium AT weiderpasse ovariancancerriskfactorsbyhistologicsubtypeananalysisfromtheovariancancercohortconsortium AT adamih ovariancancerriskfactorsbyhistologicsubtypeananalysisfromtheovariancancercohortconsortium AT blacka ovariancancerriskfactorsbyhistologicsubtypeananalysisfromtheovariancancercohortconsortium AT bernsteinl ovariancancerriskfactorsbyhistologicsubtypeananalysisfromtheovariancancercohortconsortium AT brintonl ovariancancerriskfactorsbyhistologicsubtypeananalysisfromtheovariancancercohortconsortium AT buringj ovariancancerriskfactorsbyhistologicsubtypeananalysisfromtheovariancancercohortconsortium AT butlerl ovariancancerriskfactorsbyhistologicsubtypeananalysisfromtheovariancancercohortconsortium AT chamosas ovariancancerriskfactorsbyhistologicsubtypeananalysisfromtheovariancancercohortconsortium AT clendenent ovariancancerriskfactorsbyhistologicsubtypeananalysisfromtheovariancancercohortconsortium AT dossusl ovariancancerriskfactorsbyhistologicsubtypeananalysisfromtheovariancancercohortconsortium AT fortnerr ovariancancerriskfactorsbyhistologicsubtypeananalysisfromtheovariancancercohortconsortium AT gapsturs ovariancancerriskfactorsbyhistologicsubtypeananalysisfromtheovariancancercohortconsortium AT gaudetm ovariancancerriskfactorsbyhistologicsubtypeananalysisfromtheovariancancercohortconsortium AT grami ovariancancerriskfactorsbyhistologicsubtypeananalysisfromtheovariancancercohortconsortium AT hartgep ovariancancerriskfactorsbyhistologicsubtypeananalysisfromtheovariancancercohortconsortium AT hoffmanboltonj ovariancancerriskfactorsbyhistologicsubtypeananalysisfromtheovariancancercohortconsortium AT idahla ovariancancerriskfactorsbyhistologicsubtypeananalysisfromtheovariancancercohortconsortium AT jonesm ovariancancerriskfactorsbyhistologicsubtypeananalysisfromtheovariancancercohortconsortium AT kaaksr ovariancancerriskfactorsbyhistologicsubtypeananalysisfromtheovariancancercohortconsortium AT kirshv ovariancancerriskfactorsbyhistologicsubtypeananalysisfromtheovariancancercohortconsortium AT kohw ovariancancerriskfactorsbyhistologicsubtypeananalysisfromtheovariancancercohortconsortium AT laceyj ovariancancerriskfactorsbyhistologicsubtypeananalysisfromtheovariancancercohortconsortium AT leei ovariancancerriskfactorsbyhistologicsubtypeananalysisfromtheovariancancercohortconsortium AT lundine ovariancancerriskfactorsbyhistologicsubtypeananalysisfromtheovariancancercohortconsortium AT merrittm ovariancancerriskfactorsbyhistologicsubtypeananalysisfromtheovariancancercohortconsortium AT onlandmoretn ovariancancerriskfactorsbyhistologicsubtypeananalysisfromtheovariancancercohortconsortium AT petersu ovariancancerriskfactorsbyhistologicsubtypeananalysisfromtheovariancancercohortconsortium AT poynterj ovariancancerriskfactorsbyhistologicsubtypeananalysisfromtheovariancancercohortconsortium AT rinaldis ovariancancerriskfactorsbyhistologicsubtypeananalysisfromtheovariancancercohortconsortium AT robienk ovariancancerriskfactorsbyhistologicsubtypeananalysisfromtheovariancancercohortconsortium AT rohant ovariancancerriskfactorsbyhistologicsubtypeananalysisfromtheovariancancercohortconsortium AT sandlerd ovariancancerriskfactorsbyhistologicsubtypeananalysisfromtheovariancancercohortconsortium AT schairerc ovariancancerriskfactorsbyhistologicsubtypeananalysisfromtheovariancancercohortconsortium AT schoutenl ovariancancerriskfactorsbyhistologicsubtypeananalysisfromtheovariancancercohortconsortium AT sjoholml ovariancancerriskfactorsbyhistologicsubtypeananalysisfromtheovariancancercohortconsortium AT sieris ovariancancerriskfactorsbyhistologicsubtypeananalysisfromtheovariancancercohortconsortium AT swerdlowa ovariancancerriskfactorsbyhistologicsubtypeananalysisfromtheovariancancercohortconsortium AT tjonnelanda ovariancancerriskfactorsbyhistologicsubtypeananalysisfromtheovariancancercohortconsortium AT travisr ovariancancerriskfactorsbyhistologicsubtypeananalysisfromtheovariancancercohortconsortium AT trichopouloua ovariancancerriskfactorsbyhistologicsubtypeananalysisfromtheovariancancercohortconsortium AT vandenbrandtp ovariancancerriskfactorsbyhistologicsubtypeananalysisfromtheovariancancercohortconsortium AT wilkensl ovariancancerriskfactorsbyhistologicsubtypeananalysisfromtheovariancancercohortconsortium AT wolka ovariancancerriskfactorsbyhistologicsubtypeananalysisfromtheovariancancercohortconsortium AT yangh ovariancancerriskfactorsbyhistologicsubtypeananalysisfromtheovariancancercohortconsortium AT zeleniuchjacquottea ovariancancerriskfactorsbyhistologicsubtypeananalysisfromtheovariancancercohortconsortium AT tworogers ovariancancerriskfactorsbyhistologicsubtypeananalysisfromtheovariancancercohortconsortium |