The role of corticotrophin-releasing hormone in the diagnosis of Cushing's syndrome
Background: Corticotrophin-releasing hormone (CRH) was identified by Vale and co-workers in 1981 and has since been used extensively in the diagnosis of ACTH-dependent Cushing's syndrome (CS). It was hoped that the CRH test would discriminate between pituitary and ectopic ACTH secretion. In adu...
| Prif Awduron: | , , , |
|---|---|
| Fformat: | Conference item |
| Cyhoeddwyd: |
2006
|
| _version_ | 1826279103481774080 |
|---|---|
| author | Peters, C Storr, H Grossman, AB Savage, M |
| author_facet | Peters, C Storr, H Grossman, AB Savage, M |
| author_sort | Peters, C |
| collection | OXFORD |
| description | Background: Corticotrophin-releasing hormone (CRH) was identified by Vale and co-workers in 1981 and has since been used extensively in the diagnosis of ACTH-dependent Cushing's syndrome (CS). It was hoped that the CRH test would discriminate between pituitary and ectopic ACTH secretion. In adults, a rise from basal to peak plasma cortisol of ≥ 20% and ACTH of ≥ 50% is consistent with Cushing's disease (CD). Methods: Twenty-seven paediatric patients, with CD (mean age ± S.D. 13.1 ± 3.2; range 6.4-17.8 years) were investigated in our centre between 1982 and 2005. Results: During the CRH test, all patients showed an increase in cortisol of > 20% (range 106-554%). In one patient with ectopic ACTH syndrome, there was no increase in cortisol after CRH. In six paediatric patients with CS due to primary adrenal hyperplasia, no patient showed an increase in cortisol after CRH of > 1%. Conclusions: A further suggested use of CRH is to increase the sensitivity of the central to peripheral and interpetrosal ratios of ACTH during inferior petrosal sinus catheterisation (IPSS). Bilateral IPSS with human CRH (hCRH) has been performed in our unit in 21 children with CD, as part of the preoperative preparation prior to trans-sphenoidal surgery (TSS). Its principal role was to identify the site of the microadenoma. Sixteen of 21 patients (76%) who underwent IPSS with hCRH were cured following TSS. In our view, the CRH test is of value during IPSS by clarifying the position of the microadenoma and in this way contributed to the overall outcome of TSS in paediatric patients with CD. © 2006 Society of the European Journal of Endocrinology. |
| first_indexed | 2024-03-06T23:53:48Z |
| format | Conference item |
| id | oxford-uuid:7385101d-f1fe-4e0c-9fe7-f95092822c16 |
| institution | University of Oxford |
| last_indexed | 2024-03-06T23:53:48Z |
| publishDate | 2006 |
| record_format | dspace |
| spelling | oxford-uuid:7385101d-f1fe-4e0c-9fe7-f95092822c162022-03-26T19:56:55ZThe role of corticotrophin-releasing hormone in the diagnosis of Cushing's syndromeConference itemhttp://purl.org/coar/resource_type/c_5794uuid:7385101d-f1fe-4e0c-9fe7-f95092822c16Symplectic Elements at Oxford2006Peters, CStorr, HGrossman, ABSavage, MBackground: Corticotrophin-releasing hormone (CRH) was identified by Vale and co-workers in 1981 and has since been used extensively in the diagnosis of ACTH-dependent Cushing's syndrome (CS). It was hoped that the CRH test would discriminate between pituitary and ectopic ACTH secretion. In adults, a rise from basal to peak plasma cortisol of ≥ 20% and ACTH of ≥ 50% is consistent with Cushing's disease (CD). Methods: Twenty-seven paediatric patients, with CD (mean age ± S.D. 13.1 ± 3.2; range 6.4-17.8 years) were investigated in our centre between 1982 and 2005. Results: During the CRH test, all patients showed an increase in cortisol of > 20% (range 106-554%). In one patient with ectopic ACTH syndrome, there was no increase in cortisol after CRH. In six paediatric patients with CS due to primary adrenal hyperplasia, no patient showed an increase in cortisol after CRH of > 1%. Conclusions: A further suggested use of CRH is to increase the sensitivity of the central to peripheral and interpetrosal ratios of ACTH during inferior petrosal sinus catheterisation (IPSS). Bilateral IPSS with human CRH (hCRH) has been performed in our unit in 21 children with CD, as part of the preoperative preparation prior to trans-sphenoidal surgery (TSS). Its principal role was to identify the site of the microadenoma. Sixteen of 21 patients (76%) who underwent IPSS with hCRH were cured following TSS. In our view, the CRH test is of value during IPSS by clarifying the position of the microadenoma and in this way contributed to the overall outcome of TSS in paediatric patients with CD. © 2006 Society of the European Journal of Endocrinology. |
| spellingShingle | Peters, C Storr, H Grossman, AB Savage, M The role of corticotrophin-releasing hormone in the diagnosis of Cushing's syndrome |
| title | The role of corticotrophin-releasing hormone in the diagnosis of Cushing's syndrome |
| title_full | The role of corticotrophin-releasing hormone in the diagnosis of Cushing's syndrome |
| title_fullStr | The role of corticotrophin-releasing hormone in the diagnosis of Cushing's syndrome |
| title_full_unstemmed | The role of corticotrophin-releasing hormone in the diagnosis of Cushing's syndrome |
| title_short | The role of corticotrophin-releasing hormone in the diagnosis of Cushing's syndrome |
| title_sort | role of corticotrophin releasing hormone in the diagnosis of cushing s syndrome |
| work_keys_str_mv | AT petersc theroleofcorticotrophinreleasinghormoneinthediagnosisofcushingssyndrome AT storrh theroleofcorticotrophinreleasinghormoneinthediagnosisofcushingssyndrome AT grossmanab theroleofcorticotrophinreleasinghormoneinthediagnosisofcushingssyndrome AT savagem theroleofcorticotrophinreleasinghormoneinthediagnosisofcushingssyndrome AT petersc roleofcorticotrophinreleasinghormoneinthediagnosisofcushingssyndrome AT storrh roleofcorticotrophinreleasinghormoneinthediagnosisofcushingssyndrome AT grossmanab roleofcorticotrophinreleasinghormoneinthediagnosisofcushingssyndrome AT savagem roleofcorticotrophinreleasinghormoneinthediagnosisofcushingssyndrome |