The role of the central chemoreceptor in causing periodic breathing.
In a previous publication (Fowler et al., 1993), we reduced the classical cardiorespiratory control model of (Grodins et al., 1967) to a much simpler form, which we then used to study the phenomenon of periodic breathing. In particular, cardiac output was assumed constant, and a single (constant) de...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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2000
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| _version_ | 1797075690331308032 |
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| author | Fowler, A Kalamangalam, G |
| author_facet | Fowler, A Kalamangalam, G |
| author_sort | Fowler, A |
| collection | OXFORD |
| description | In a previous publication (Fowler et al., 1993), we reduced the classical cardiorespiratory control model of (Grodins et al., 1967) to a much simpler form, which we then used to study the phenomenon of periodic breathing. In particular, cardiac output was assumed constant, and a single (constant) delay representing arterial blood transport time between lung and brain was included in the model. In this paper we extend this earlier work, both by allowing for the variability in transport delays, due to the dependence of cardiac output on blood gas concentrations, and also by including further delays in the system. In addition, we extensively discuss the physiological implications of parameter variations in the model; several novel mechanisms for periodic breathing in clinical situations are proposed. The results are discussed in the light of recent observational studies. |
| first_indexed | 2024-03-06T23:53:49Z |
| format | Journal article |
| id | oxford-uuid:7385fcad-932e-46c5-8676-76cfacaf4c84 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:53:49Z |
| publishDate | 2000 |
| record_format | dspace |
| spelling | oxford-uuid:7385fcad-932e-46c5-8676-76cfacaf4c842022-03-26T19:56:57ZThe role of the central chemoreceptor in causing periodic breathing.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:7385fcad-932e-46c5-8676-76cfacaf4c84EnglishSymplectic Elements at Oxford2000Fowler, AKalamangalam, GIn a previous publication (Fowler et al., 1993), we reduced the classical cardiorespiratory control model of (Grodins et al., 1967) to a much simpler form, which we then used to study the phenomenon of periodic breathing. In particular, cardiac output was assumed constant, and a single (constant) delay representing arterial blood transport time between lung and brain was included in the model. In this paper we extend this earlier work, both by allowing for the variability in transport delays, due to the dependence of cardiac output on blood gas concentrations, and also by including further delays in the system. In addition, we extensively discuss the physiological implications of parameter variations in the model; several novel mechanisms for periodic breathing in clinical situations are proposed. The results are discussed in the light of recent observational studies. |
| spellingShingle | Fowler, A Kalamangalam, G The role of the central chemoreceptor in causing periodic breathing. |
| title | The role of the central chemoreceptor in causing periodic breathing. |
| title_full | The role of the central chemoreceptor in causing periodic breathing. |
| title_fullStr | The role of the central chemoreceptor in causing periodic breathing. |
| title_full_unstemmed | The role of the central chemoreceptor in causing periodic breathing. |
| title_short | The role of the central chemoreceptor in causing periodic breathing. |
| title_sort | role of the central chemoreceptor in causing periodic breathing |
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