Triple artemisinin-based combination therapies for malaria – a new paradigm?
Recent gains in the fight against malaria are threatened by the emergence and spread of artemisinin and partner drug resistance in Plasmodium falciparum in the Greater Mekong Subregion (GMS). When artemisinins are combined with a single partner drug, all recommended artemisinin-based combination the...
| Main Authors: | , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
Elsevier
2020
|
| _version_ | 1797075702662561792 |
|---|---|
| author | van der Pluijm, RW Amaratunga, C Dhorda, M Dondorp, AM |
| author_facet | van der Pluijm, RW Amaratunga, C Dhorda, M Dondorp, AM |
| author_sort | van der Pluijm, RW |
| collection | OXFORD |
| description | Recent gains in the fight against malaria are threatened by the emergence and spread of artemisinin and partner drug resistance in Plasmodium falciparum in the Greater Mekong Subregion (GMS). When artemisinins are combined with a single partner drug, all recommended artemisinin-based combination therapies have shown reduced efficacy in some countries in the GMS at some point. Novel drugs are not available for the near future. Triple artemisinin-based combination therapies, combining artemisinins with two currently available partner drugs, will provide one of the last remaining safe and effective treatments for falciparum malaria that can be deployed rapidly in the GMS, whereas their deployment beyond the GMS could delay or prevent the global emergence and spread of resistance to currently available drugs. |
| first_indexed | 2024-03-06T23:54:00Z |
| format | Journal article |
| id | oxford-uuid:73964964-3db5-47a2-b2aa-a8df4a57548e |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:54:00Z |
| publishDate | 2020 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:73964964-3db5-47a2-b2aa-a8df4a57548e2022-03-26T19:57:21ZTriple artemisinin-based combination therapies for malaria – a new paradigm?Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:73964964-3db5-47a2-b2aa-a8df4a57548eEnglishSymplectic ElementsElsevier2020van der Pluijm, RWAmaratunga, CDhorda, MDondorp, AMRecent gains in the fight against malaria are threatened by the emergence and spread of artemisinin and partner drug resistance in Plasmodium falciparum in the Greater Mekong Subregion (GMS). When artemisinins are combined with a single partner drug, all recommended artemisinin-based combination therapies have shown reduced efficacy in some countries in the GMS at some point. Novel drugs are not available for the near future. Triple artemisinin-based combination therapies, combining artemisinins with two currently available partner drugs, will provide one of the last remaining safe and effective treatments for falciparum malaria that can be deployed rapidly in the GMS, whereas their deployment beyond the GMS could delay or prevent the global emergence and spread of resistance to currently available drugs. |
| spellingShingle | van der Pluijm, RW Amaratunga, C Dhorda, M Dondorp, AM Triple artemisinin-based combination therapies for malaria – a new paradigm? |
| title | Triple artemisinin-based combination therapies for malaria – a new paradigm? |
| title_full | Triple artemisinin-based combination therapies for malaria – a new paradigm? |
| title_fullStr | Triple artemisinin-based combination therapies for malaria – a new paradigm? |
| title_full_unstemmed | Triple artemisinin-based combination therapies for malaria – a new paradigm? |
| title_short | Triple artemisinin-based combination therapies for malaria – a new paradigm? |
| title_sort | triple artemisinin based combination therapies for malaria a new paradigm |
| work_keys_str_mv | AT vanderpluijmrw tripleartemisininbasedcombinationtherapiesformalariaanewparadigm AT amaratungac tripleartemisininbasedcombinationtherapiesformalariaanewparadigm AT dhordam tripleartemisininbasedcombinationtherapiesformalariaanewparadigm AT dondorpam tripleartemisininbasedcombinationtherapiesformalariaanewparadigm |