Rapid dose-dependent Natural Killer (NK) cell modulation and cytokine responses following human rVSV-ZEBOV Ebolavirus vaccination
The rVSV-ZEBOV Ebolavirus vaccine confers protection within days after immunization, suggesting the contribution of innate immune responses. We report modulation of rVSV-ZEBOV vaccinee blood CD56+ NK cell numbers, NKG2D or NKp30 surface receptor expression, Killer Immunoglobulin-like Receptor (KIR)+...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Other Authors: | |
| Format: | Journal article |
| Language: | English |
| Published: |
Springer Nature
2020
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| _version_ | 1797075735014277120 |
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| author | Pejoski, D de Rham, C Martinez-Murillo, P Santoro, F Auderset, F Medaglini, D Pozzi, G Vono, M Lambert, P-H Huttner, A Haks, MC Ottenhoff, THM Villard, J Siegrist, C-A VEBCON Consortium VSV-EBOVAC Consortium VSV-EBOPLUS Consortium |
| author2 | Bejon, P |
| author_facet | Bejon, P Pejoski, D de Rham, C Martinez-Murillo, P Santoro, F Auderset, F Medaglini, D Pozzi, G Vono, M Lambert, P-H Huttner, A Haks, MC Ottenhoff, THM Villard, J Siegrist, C-A VEBCON Consortium VSV-EBOVAC Consortium VSV-EBOPLUS Consortium |
| author_sort | Pejoski, D |
| collection | OXFORD |
| description | The rVSV-ZEBOV Ebolavirus vaccine confers protection within days after immunization, suggesting the contribution of innate immune responses. We report modulation of rVSV-ZEBOV vaccinee blood CD56+ NK cell numbers, NKG2D or NKp30 surface receptor expression, Killer Immunoglobulin-like Receptor (KIR)+ cell percentages and NK-cell-related genes on day 1 post immunization. Inverse correlations existed between the concentration of several plasma cytokines and inhibitory KIR+ CD56dim or cytokine-responsive CD56bright NK cells. Thus, NK cells may contribute to the early protective efficacy of rVSV-ZEBOV in humans. |
| first_indexed | 2024-03-06T23:54:23Z |
| format | Journal article |
| id | oxford-uuid:73b10451-3994-4c13-8290-04857ceeaba3 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:54:23Z |
| publishDate | 2020 |
| publisher | Springer Nature |
| record_format | dspace |
| spelling | oxford-uuid:73b10451-3994-4c13-8290-04857ceeaba32022-03-26T19:58:14ZRapid dose-dependent Natural Killer (NK) cell modulation and cytokine responses following human rVSV-ZEBOV Ebolavirus vaccinationJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:73b10451-3994-4c13-8290-04857ceeaba3EnglishSymplectic ElementsSpringer Nature2020Pejoski, Dde Rham, CMartinez-Murillo, PSantoro, FAuderset, FMedaglini, DPozzi, GVono, MLambert, P-HHuttner, AHaks, MCOttenhoff, THMVillard, JSiegrist, C-AVEBCON ConsortiumVSV-EBOVAC ConsortiumVSV-EBOPLUS ConsortiumBejon, PNdungu, FThe rVSV-ZEBOV Ebolavirus vaccine confers protection within days after immunization, suggesting the contribution of innate immune responses. We report modulation of rVSV-ZEBOV vaccinee blood CD56+ NK cell numbers, NKG2D or NKp30 surface receptor expression, Killer Immunoglobulin-like Receptor (KIR)+ cell percentages and NK-cell-related genes on day 1 post immunization. Inverse correlations existed between the concentration of several plasma cytokines and inhibitory KIR+ CD56dim or cytokine-responsive CD56bright NK cells. Thus, NK cells may contribute to the early protective efficacy of rVSV-ZEBOV in humans. |
| spellingShingle | Pejoski, D de Rham, C Martinez-Murillo, P Santoro, F Auderset, F Medaglini, D Pozzi, G Vono, M Lambert, P-H Huttner, A Haks, MC Ottenhoff, THM Villard, J Siegrist, C-A VEBCON Consortium VSV-EBOVAC Consortium VSV-EBOPLUS Consortium Rapid dose-dependent Natural Killer (NK) cell modulation and cytokine responses following human rVSV-ZEBOV Ebolavirus vaccination |
| title | Rapid dose-dependent Natural Killer (NK) cell modulation and cytokine responses following human rVSV-ZEBOV Ebolavirus vaccination |
| title_full | Rapid dose-dependent Natural Killer (NK) cell modulation and cytokine responses following human rVSV-ZEBOV Ebolavirus vaccination |
| title_fullStr | Rapid dose-dependent Natural Killer (NK) cell modulation and cytokine responses following human rVSV-ZEBOV Ebolavirus vaccination |
| title_full_unstemmed | Rapid dose-dependent Natural Killer (NK) cell modulation and cytokine responses following human rVSV-ZEBOV Ebolavirus vaccination |
| title_short | Rapid dose-dependent Natural Killer (NK) cell modulation and cytokine responses following human rVSV-ZEBOV Ebolavirus vaccination |
| title_sort | rapid dose dependent natural killer nk cell modulation and cytokine responses following human rvsv zebov ebolavirus vaccination |
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