Understanding the genetic relationship between key effectors of DNA interstrand crosslink repair
<p>With each cell division, our whole genome is duplicated in an error-free and controlled manner. Failure to do so leads to genomic instability. DNA interstrand crosslinks (ICLs) are particularly toxic DNA lesions as when left unrepaired, they are able to block replication producing devastati...
Үндсэн зохиолч: | Brolih, S |
---|---|
Бусад зохиолчид: | McHugh, P |
Формат: | Дипломын ажил |
Хэвлэсэн: |
2016
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Ижил төстэй зүйлс
Ижил төстэй зүйлс
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WRNIP1 is recruited to DNA interstrand crosslinks and promotes repair
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RPA activates the XPF-ERCC1 endonuclease to initiate processing of DNA interstrand crosslinks.
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