Understanding the genetic relationship between key effectors of DNA interstrand crosslink repair

Understanding the genetic relationship between key effectors of DNA interstrand crosslink repair

<p>With each cell division, our whole genome is duplicated in an error-free and controlled manner. Failure to do so leads to genomic instability. DNA interstrand crosslinks (ICLs) are particularly toxic DNA lesions as when left unrepaired, they are able to block replication producing devastati...

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Bibliografische gegevens
Hoofdauteur:	Brolih, S
Andere auteurs:	McHugh, P
Formaat:	Thesis
Gepubliceerd in:	2016

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RPA activates the XPF-ERCC1 endonuclease to initiate processing of DNA interstrand crosslinks.
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RPA activates the XPF‐ERCC1 endonuclease to initiate processing of DNA interstrand crosslinks
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UHRF1 is a sensor for DNA interstrand crosslinks.
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DNA interstrand crosslink repair during G1 involves nucleotide excision repair and DNA polymerase zeta.
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Identification of novel players implicated in replication-dependent and independent DNA interstrand crosslink (ICL) repair
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Cellular response to DNA interstrand crosslinks: The Fanconi Anemia pathway
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Coordinated Cut and Bypass: Replication of Interstrand Crosslink-Containing DNA
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CtIP is required to initiate replication-dependent interstrand crosslink repair.
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Components of a Fanconi-like pathway control Pso2-independent DNA interstrand crosslink repair in yeast
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Components of a Fanconi-like pathway control Pso2-independent DNA interstrand crosslink repair in yeast.
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Identification of UHRF2 as a novel DNA interstrand crosslink sensor protein
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CSB interacts with SNM1A and promotes DNA interstrand crosslink processing.
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Identification of UHRF2 as a novel DNA interstrand crosslink sensor protein.
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DNA interstrand cross-link repair in Saccharomyces cerevisiae.
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Single Molecule Analysis of Laser Localized Interstrand Crosslinks
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Histone demethylase AMX-1 is necessary for proper sensitivity to interstrand crosslink DNA damage.
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The FANCD2-FANCI complex is recruited to DNA interstrand crosslinks prior to monoubiquitination of FANCD2
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The FANCD2–FANCI complex is recruited to DNA interstrand crosslinks before monoubiquitination of FANCD2
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Dual targeting of <i>Saccharomyces cerevisiae</i> Pso2 to mitochondria and the nucleus, and its functional relevance in the repair of DNA interstrand crosslinks
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Human MLH1 protein participates in genomic damage checkpoint signaling in response to DNA interstrand crosslinks, while MSH2 functions in DNA repair.
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Orchestrating the nucleases involved in DNA interstrand cross-link (ICL) repair.
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DNA interstrand cross-link repair requires replication-fork convergence
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The analysis of DNA interstrand cross-links and their repair by the modified comet assay
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DNA interstrand cross-link repair requires replication-fork convergence
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C. elegans ring finger protein RNF-113 is involved in interstrand DNA crosslink repair and interacts with a RAD51C homolog.
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Gepubliceerd in: (2013-01-01)

ATR-p53 restricts homologous recombination in response to replicative stress but does not limit DNA interstrand crosslink repair in lung cancer cells.
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Drosophila DNA polymerase theta utilizes both helicase-like and polymerase domains during microhomology-mediated end joining and interstrand crosslink repair.
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Cisplatin sensitivity of testis tumour cells is due to deficiency in interstrand-crosslink repair and low ERCC1-XPF expression
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UHRF1 Is a sensor for DNA interstrand crosslinks and recruits FANCD2 to initiate the Fanconi Anemia pathway
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UHRF1 Is a Sensor for DNA Interstrand Crosslinks and Recruits FANCD2 to Initiate the Fanconi Anemia Pathway
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DNA double strand breaks but not interstrand crosslinks prevent progress through meiosis in fully grown mouse oocytes.
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