Understanding the genetic relationship between key effectors of DNA interstrand crosslink repair
<p>With each cell division, our whole genome is duplicated in an error-free and controlled manner. Failure to do so leads to genomic instability. DNA interstrand crosslinks (ICLs) are particularly toxic DNA lesions as when left unrepaired, they are able to block replication producing devastati...
Huvudupphovsman: | Brolih, S |
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Övriga upphovsmän: | McHugh, P |
Materialtyp: | Lärdomsprov |
Publicerad: |
2016
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Liknande verk
Liknande verk
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The role of PARPs and APLF in DNA interstrand crosslink repair
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The role of ADP-ribosylation in regulating DNA interstrand crosslink repair
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WRNIP1 is recruited to DNA interstrand crosslinks and promotes repair
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RPA activates the XPF-ERCC1 endonuclease to initiate processing of DNA interstrand crosslinks.
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RPA activates the XPF‐ERCC1 endonuclease to initiate processing of DNA interstrand crosslinks
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