The structure of the N-terminus of kindlin-1: a domain important for alphaiibbeta3 integrin activation.
The integrin family of heterodimeric cell adhesion molecules exists in both low- and high-affinity states, and integrin activation requires binding of the talin FERM (four-point-one, ezrin, radixin, moesin) domain to membrane-proximal sequences in the beta-integrin cytoplasmic domain. However, it ha...
| Main Authors: | , , , , , , , , , , |
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| 格式: | Journal article |
| 語言: | English |
| 出版: |
2009
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