Immune responses in advanced colorectal cancer following repeated intradermal vaccination with the anti-CEA murine monoclonal antibody, PR1A3: results of a phase I study.

Immune responses in advanced colorectal cancer following repeated intradermal vaccination with the anti-CEA murine monoclonal antibody, PR1A3: results of a phase I study.

BACKGROUND AND AIMS: The aim was to determine the toxicity, clinical and immune responses to the murine monoclonal anti-carcinoembryonic antigen (CEA) antibody, PR1A3, in patients with advanced colorectal cancer. MATERIALS AND METHODS: Fifteen patients with advanced colorectal cancer received eithe...

Full description

Bibliographic Details
Main Authors:	Zbar, A, Thomas, H, Wilkinson, R, Wadhwa, M, Syrigos, K, Ross, E, Dilger, P, Allen-Mersh, T, Kmiot, W, Epenetos, A, Snary, D, Bodmer, W
Format:	Journal article
Language:	English
Published:	2005

Similar Items

CEA-targeted monoclonal antibody therapy in colorectal cancer
by: Conaghan, P, et al.
Published: (2009)

Reply: In vitro and in vivo anticancer efficacy of unconjugated humanised anti-CEA monoclonal antibodies
by: Ashraf, S, et al.
Published: (2008)

Antibody targeting studies in a transgenic murine model of spontaneous colorectal tumors.
by: Wilkinson, R, et al.
Published: (2001)

CEA monitoring in colorectal cancer is not a waste of time.
by: Mant, D, et al.
Published: (2014)

Optimization of serum free medium for the production of humanized anti-cea monoclonal antibody.
by: Ab Latif, Nurzila
Published: (2011)

Targeted killing of colorectal cell lines and murine adenomas using a monoclonal antibody against membrane bound carcinoembryonic antigen
by: Conaghan, P, et al.
Published: (2006)

Blood CEA levels for detecting recurrent colorectal cancer: A Diagnostic Test Accuracy Review.
by: Nicholson, B, et al.
Published: (2015)

Assessment of preclinical models for colorectal cancer
by: Wilkinson, R, et al.
Published: (2001)

Carcinoembryonic antigen (CEA) inhibits NK killing via interaction with CEA-related cell adhesion molecule 1.
by: Stern, N, et al.
Published: (2005)

An immunohistological study of testicular germ cell tumours using two different monoclonal antibodies against placental alkaline phosphatase.
by: Epenetos, A, et al.
Published: (1984)

Bypassing immunization: optimized design of "designer T cells" against carcinoembryonic antigen (CEA)-expressing tumors, and lack of suppression by soluble CEA.
by: Nolan, K, et al.
Published: (1999)

The diagnostic accuracy of a single CEA blood test in detecting colorectal cancer recurrence: Results from the FACS trial.
by: Shinkins, B, et al.
Published: (2017)

Performance verification of the MIRI Imager flight model at CEA
by: Ronayette, S, et al.
Published: (2010)

Applicability of carcinoembryonic antigen-specific monoclonal antibodies to radioimmunoguided surgery for human colorectal carcinoma.
by: Kim, J, et al.
Published: (2000)

Intradermal post-exposure rabies vaccination.
by: Warrell, M, et al.
Published: (1986)

Intradermal postexposure rabies vaccine regimens.
by: Warrell, M, et al.
Published: (2000)

Effect of 3 to 5 years of scheduled CEA and CT follow-up to detect recurrence of colorectal cancer: the FACS randomized clinical trial.
by: Primrose, J, et al.
Published: (2014)

Effect of 3-5 years of scheduled CEA and CT follow-up to detect recurrence of colorectal cancer: FACS randomized controlled trial.
by: Mant, D, et al.
Published: (2013)

Intradermal powder immunization with protein-containing vaccines.
by: Weissmueller, N, et al.
Published: (2013)

Intradermal needle-free powdered drug injection
by: Liu, John (John Hsiao-Yung)
Published: (2012)

A novel carcinoembryonic antigen t cell bispecific antibody (cea tcb) for the treatment of solid tumors
by: Bacac, M, et al.
Published: (2016)

Monoclonal antibodies to HLA--DRw determinants.
by: Brodsky, F, et al.
Published: (1980)

Scheduled use of CEA and CT follow-up to detect recurrence of colorectal cancer: 6-12 year results from the FACS randomised controlled trial
by: Pugh, SA, et al.
Published: (2018)

β-PrP form of human prion protein stimulates production of monoclonal antibodies to epitope 91–110 that recognise native PrPSc
by: Khalili-Shirazi, A, et al.
Published: (2007)

Genetics of colorectal cancer: hereditary aspects and overview of colorectal tumorigenesis.
by: Fearnhead, N, et al.
Published: (2002)

Microneedle‐based intradermal delivery of stabilized dengue virus
by: Turvey, Michelle E., et al.
Published: (2020)

Intradermal regimens for rabies postexposure prophylaxis: more confusion.
by: Warrell, M, et al.
Published: (2002)

Cancer genetics: colorectal cancer as a model.
by: Bodmer, W
Published: (2006)

Optical feedback cavity-enhanced absorption spectroscopy (OF-CEAS) in a ring cavity
by: Hamilton, D, et al.
Published: (2010)

Enhancement of colorectal tumor targeting using a novel biparatopic monoclonal antibody against carcinoembryonic antigen in experimental radioimmunoguided surgery.
by: Kim, J, et al.
Published: (2002)

Monoclonal antibodies for analysis of the HLA system.
by: Brodsky, F, et al.
Published: (1979)

Monoclonal antibody to a human histocompatibility alloantigen, HLA-A2.
by: Parham, P, et al.
Published: (1978)

Surface enhanced Raman spectroscopy for malaria diagnosis and intradermal measurements
by: Yuen, Clement, et al.
Published: (2018)

ZnO nano-rod devices for intradermal delivery and immunization
by: Nayak, Tapas R., et al.
Published: (2018)

MONOCLONAL-ANTIBODIES AGAINST HUMAN C-3
by: Whitehead, A, et al.
Published: (1980)

Targeted killing of colorectal cancer cell lines by a humanised IgG1 monoclonal antibody that binds to membrane-bound carcinoembryonic antigen.
by: Conaghan, P, et al.
Published: (2008)

Hypoxia and lineage specification of colorectal cancer stem cells
by: Yeung, T, et al.
Published: (2012)

A MONOCLONAL-ANTIBODY TO SPECIFIC HUMAN EPIDERMAL-CELL LAYERS
by: Goldsmith, L, et al.
Published: (1980)

Intradermal cytosine-phosphate-guanosine treatment reduces lung inflammation but induces IFN-γ-mediated airway hyperreactivity in a murine model of natural rubber latex allergy.
by: Haapakoski, R, et al.
Published: (2011)

Epigenetic control of CD24 expression in colorectal cancer
by: Ayub, M, et al.
Published: (2016)