Multivalent protein binding and precipitation by self-assembling molecules on a DNA pentaplex scaffold.

A supramolecular assembly containing an isoguanosine pentaplex with both a "protein-binding" face and a "reporter" face has been generated. When phosphocholine is appended to the protein-binding face this supramolecular assembly binds multivalently to the pentameric human C-react...

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Автори: Rosenzweig, B, Ross, N, Tagore, D, Jayawickramarajah, J, Saraogi, I, Hamilton, A
Формат: Journal article
Мова:English
Опубліковано: 2009
Опис
Резюме:A supramolecular assembly containing an isoguanosine pentaplex with both a "protein-binding" face and a "reporter" face has been generated. When phosphocholine is appended to the protein-binding face this supramolecular assembly binds multivalently to the pentameric human C-reactive protein, a biomolecule implicated in inflammation and heart disease.