Antimalarial drug resistance, artemisinin-based combination therapy, and the contribution of modeling to elucidating policy choices.
Increasing resistance of Plasmodium falciparum malaria to antimalarial drugs is posing a major threat to the global effort to "Roll Back Malaria". Chloroquine and sulfadoxine-pyrimethamine (SP) are being rendered increasingly ineffective, resulting in increasing morbidity, mortality, and e...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
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2004
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| _version_ | 1797075855110832128 |
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| author | Yeung, S Pongtavornpinyo, W Hastings, I Mills, A White, N |
| author_facet | Yeung, S Pongtavornpinyo, W Hastings, I Mills, A White, N |
| author_sort | Yeung, S |
| collection | OXFORD |
| description | Increasing resistance of Plasmodium falciparum malaria to antimalarial drugs is posing a major threat to the global effort to "Roll Back Malaria". Chloroquine and sulfadoxine-pyrimethamine (SP) are being rendered increasingly ineffective, resulting in increasing morbidity, mortality, and economic and social costs. One strategy advocated for delaying the development of resistance to the remaining armory of effective drugs is the wide-scale deployment of artemisinin-based combination therapy. However, the cost of these combinations are higher than most of the currently used monotherapies and alternative non-artemisinin-based combinations. In addition, uncertainty about the actual impact in real-life settings has made them a controversial choice for first-line treatment. The difficulties in measuring the burden of drug resistance and predicting the impact of strategies aimed at its reduction are outlined, and a mathematical model is introduced that is being designed to address these issues and to clarify policy options. |
| first_indexed | 2024-03-06T23:56:06Z |
| format | Journal article |
| id | oxford-uuid:7447c6bb-f1da-498a-9de2-f7d7b6c6f2c7 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:56:06Z |
| publishDate | 2004 |
| record_format | dspace |
| spelling | oxford-uuid:7447c6bb-f1da-498a-9de2-f7d7b6c6f2c72022-03-26T20:01:38ZAntimalarial drug resistance, artemisinin-based combination therapy, and the contribution of modeling to elucidating policy choices.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:7447c6bb-f1da-498a-9de2-f7d7b6c6f2c7EnglishSymplectic Elements at Oxford2004Yeung, SPongtavornpinyo, WHastings, IMills, AWhite, NIncreasing resistance of Plasmodium falciparum malaria to antimalarial drugs is posing a major threat to the global effort to "Roll Back Malaria". Chloroquine and sulfadoxine-pyrimethamine (SP) are being rendered increasingly ineffective, resulting in increasing morbidity, mortality, and economic and social costs. One strategy advocated for delaying the development of resistance to the remaining armory of effective drugs is the wide-scale deployment of artemisinin-based combination therapy. However, the cost of these combinations are higher than most of the currently used monotherapies and alternative non-artemisinin-based combinations. In addition, uncertainty about the actual impact in real-life settings has made them a controversial choice for first-line treatment. The difficulties in measuring the burden of drug resistance and predicting the impact of strategies aimed at its reduction are outlined, and a mathematical model is introduced that is being designed to address these issues and to clarify policy options. |
| spellingShingle | Yeung, S Pongtavornpinyo, W Hastings, I Mills, A White, N Antimalarial drug resistance, artemisinin-based combination therapy, and the contribution of modeling to elucidating policy choices. |
| title | Antimalarial drug resistance, artemisinin-based combination therapy, and the contribution of modeling to elucidating policy choices. |
| title_full | Antimalarial drug resistance, artemisinin-based combination therapy, and the contribution of modeling to elucidating policy choices. |
| title_fullStr | Antimalarial drug resistance, artemisinin-based combination therapy, and the contribution of modeling to elucidating policy choices. |
| title_full_unstemmed | Antimalarial drug resistance, artemisinin-based combination therapy, and the contribution of modeling to elucidating policy choices. |
| title_short | Antimalarial drug resistance, artemisinin-based combination therapy, and the contribution of modeling to elucidating policy choices. |
| title_sort | antimalarial drug resistance artemisinin based combination therapy and the contribution of modeling to elucidating policy choices |
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