Mechanochemical models for generating biological pattern and form in development
The central issue in development is the formation of spatial patterns of cells in the early embryo. The mechanisms which generate these patterns are unknown. Here we describe the new Oster-Murray mechanochemical approach to the problem, the elements of which are experimentally well documented. By wa...
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| Format: | Journal article |
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1988
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| _version_ | 1797075862546284544 |
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| author | Murray, J Maini, P Tranquillo, R |
| author_facet | Murray, J Maini, P Tranquillo, R |
| author_sort | Murray, J |
| collection | OXFORD |
| description | The central issue in development is the formation of spatial patterns of cells in the early embryo. The mechanisms which generate these patterns are unknown. Here we describe the new Oster-Murray mechanochemical approach to the problem, the elements of which are experimentally well documented. By way of illustration we derive one of the basic models from first principles and apply it to a variety of problems of current interest and research. We specifically discuss the formation of skin organ patterns, such as feather and scale germs, cartilage condensations in the developing vertebrate limb and finally wound healing. |
| first_indexed | 2024-03-06T23:56:13Z |
| format | Journal article |
| id | oxford-uuid:744fb359-b5cb-4591-ac9b-6124b2359d32 |
| institution | University of Oxford |
| last_indexed | 2024-03-06T23:56:13Z |
| publishDate | 1988 |
| record_format | dspace |
| spelling | oxford-uuid:744fb359-b5cb-4591-ac9b-6124b2359d322022-03-26T20:01:56ZMechanochemical models for generating biological pattern and form in developmentJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:744fb359-b5cb-4591-ac9b-6124b2359d32Mathematical Institute - ePrints1988Murray, JMaini, PTranquillo, RThe central issue in development is the formation of spatial patterns of cells in the early embryo. The mechanisms which generate these patterns are unknown. Here we describe the new Oster-Murray mechanochemical approach to the problem, the elements of which are experimentally well documented. By way of illustration we derive one of the basic models from first principles and apply it to a variety of problems of current interest and research. We specifically discuss the formation of skin organ patterns, such as feather and scale germs, cartilage condensations in the developing vertebrate limb and finally wound healing. |
| spellingShingle | Murray, J Maini, P Tranquillo, R Mechanochemical models for generating biological pattern and form in development |
| title | Mechanochemical models for generating biological pattern and form in development |
| title_full | Mechanochemical models for generating biological pattern and form in development |
| title_fullStr | Mechanochemical models for generating biological pattern and form in development |
| title_full_unstemmed | Mechanochemical models for generating biological pattern and form in development |
| title_short | Mechanochemical models for generating biological pattern and form in development |
| title_sort | mechanochemical models for generating biological pattern and form in development |
| work_keys_str_mv | AT murrayj mechanochemicalmodelsforgeneratingbiologicalpatternandformindevelopment AT mainip mechanochemicalmodelsforgeneratingbiologicalpatternandformindevelopment AT tranquillor mechanochemicalmodelsforgeneratingbiologicalpatternandformindevelopment |