Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis

Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis

Switching to a glycolytic metabolism is a rapid adaptation of tumor cells to hypoxia. Although this metabolic conversion may primarily represent a rescue pathway to meet the bioenergetic and biosynthetic demands of proliferating tumor cells, it also creates a gradient of lactate that mirrors the gra...

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Những tác giả chính: Sonveaux, P, Copetti, T, De Saedeleer, CJ, Végran, F, Verrax, J, Kennedy, KM, Moon, EJ, Dhup, S, Danhier, P, Frérart, F, Gallez, B, Ribeiro, A, Michiels, C, Dewhirst, MW, Feron, O
Định dạng: Journal article
Ngôn ngữ:English
Được phát hành: Public Library of Science 2012

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