Meta-analysis of the effects of n-3 polyunsaturated fatty acids on haematological and thrombogenic factors in type 2 diabetes
Aim/hypothesis: To determine whether marine-derived n-3 polyunsaturated fatty acids (n-3 PUFA) (also known as omega-3 fatty acids) have beneficial effects on haematological and thrombogenic risk markers in addition to dyslipidaemia, in patients with type 2 diabetes. Methods: A systematic review and...
| मुख्य लेखकों: | , , , |
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| अन्य लेखक: | |
| स्वरूप: | Journal article |
| भाषा: | English |
| प्रकाशित: |
Springer
2007
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| विषय: |
| _version_ | 1826279302920929280 |
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| author | Hartweg, J Farmer, A Holman, R Neil, H |
| author2 | European Society for the Study of Diabetes |
| author_facet | European Society for the Study of Diabetes Hartweg, J Farmer, A Holman, R Neil, H |
| author_sort | Hartweg, J |
| collection | OXFORD |
| description | Aim/hypothesis: To determine whether marine-derived n-3 polyunsaturated fatty acids (n-3 PUFA) (also known as omega-3 fatty acids) have beneficial effects on haematological and thrombogenic risk markers in addition to dyslipidaemia, in patients with type 2 diabetes. Methods: A systematic review and meta-analysis of randomised controlled trials compary dietary or non-dietary intake of n-3 PUFA with placebo in type 2 diabetes was conducted by systematically searching databases from 1966 to February 2006. Changes in C-reactive protein, IL-6, TNF-α, platelet function, fibrinogen, factor VII, von Willebrand factor, endothelial function, heart rate and blood pressure were recorded. Inclusion of studies, data extraction and quality were assessed independently in duplicate. Results: Tweleve trials involving 847 subjects with a mean treatment duration of 8.5 weeks included sufficient data to permit pooling. Cpmpared with placebo, n-3 PUFA supplementation had a significant effect on two outcomes: reducing the level of diastolic blood pressure (five trials, 248 subjects) by a mean of 1.8 mm Hg (95% CI 0.0-3.6, p=0.05) and increasing factor VII (two trials, 116 subjects) by 24% (95% CI 7.2-42.6, p=0.006). There were no significant effects on systolic blood pressure, fibrinogen or heart rate. Conclusions/interpretation: These results suggest that, in addition to the recognised effects on dyslipidaemia, n-3 PUFA decreases diastolic blood pressure, and appears to increase factor VII. Larger and more rigorously conducted clinical trials are required to establish conclusively the role of n-3 PUFA in cardiovascular risk markers and clinical outcomes in type 2 diabetes. |
| first_indexed | 2024-03-06T23:56:42Z |
| format | Journal article |
| id | oxford-uuid:7474d10d-4a92-48f3-ae8f-a0b4b2fd6ebb |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:56:42Z |
| publishDate | 2007 |
| publisher | Springer |
| record_format | dspace |
| spelling | oxford-uuid:7474d10d-4a92-48f3-ae8f-a0b4b2fd6ebb2022-03-26T20:02:59ZMeta-analysis of the effects of n-3 polyunsaturated fatty acids on haematological and thrombogenic factors in type 2 diabetesJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:7474d10d-4a92-48f3-ae8f-a0b4b2fd6ebbDiabetesPublic HealthEnglishOxford University Research Archive - ValetSpringer2007Hartweg, JFarmer, AHolman, RNeil, HEuropean Society for the Study of DiabetesAim/hypothesis: To determine whether marine-derived n-3 polyunsaturated fatty acids (n-3 PUFA) (also known as omega-3 fatty acids) have beneficial effects on haematological and thrombogenic risk markers in addition to dyslipidaemia, in patients with type 2 diabetes. Methods: A systematic review and meta-analysis of randomised controlled trials compary dietary or non-dietary intake of n-3 PUFA with placebo in type 2 diabetes was conducted by systematically searching databases from 1966 to February 2006. Changes in C-reactive protein, IL-6, TNF-α, platelet function, fibrinogen, factor VII, von Willebrand factor, endothelial function, heart rate and blood pressure were recorded. Inclusion of studies, data extraction and quality were assessed independently in duplicate. Results: Tweleve trials involving 847 subjects with a mean treatment duration of 8.5 weeks included sufficient data to permit pooling. Cpmpared with placebo, n-3 PUFA supplementation had a significant effect on two outcomes: reducing the level of diastolic blood pressure (five trials, 248 subjects) by a mean of 1.8 mm Hg (95% CI 0.0-3.6, p=0.05) and increasing factor VII (two trials, 116 subjects) by 24% (95% CI 7.2-42.6, p=0.006). There were no significant effects on systolic blood pressure, fibrinogen or heart rate. Conclusions/interpretation: These results suggest that, in addition to the recognised effects on dyslipidaemia, n-3 PUFA decreases diastolic blood pressure, and appears to increase factor VII. Larger and more rigorously conducted clinical trials are required to establish conclusively the role of n-3 PUFA in cardiovascular risk markers and clinical outcomes in type 2 diabetes. |
| spellingShingle | Diabetes Public Health Hartweg, J Farmer, A Holman, R Neil, H Meta-analysis of the effects of n-3 polyunsaturated fatty acids on haematological and thrombogenic factors in type 2 diabetes |
| title | Meta-analysis of the effects of n-3 polyunsaturated fatty acids on haematological and thrombogenic factors in type 2 diabetes |
| title_full | Meta-analysis of the effects of n-3 polyunsaturated fatty acids on haematological and thrombogenic factors in type 2 diabetes |
| title_fullStr | Meta-analysis of the effects of n-3 polyunsaturated fatty acids on haematological and thrombogenic factors in type 2 diabetes |
| title_full_unstemmed | Meta-analysis of the effects of n-3 polyunsaturated fatty acids on haematological and thrombogenic factors in type 2 diabetes |
| title_short | Meta-analysis of the effects of n-3 polyunsaturated fatty acids on haematological and thrombogenic factors in type 2 diabetes |
| title_sort | meta analysis of the effects of n 3 polyunsaturated fatty acids on haematological and thrombogenic factors in type 2 diabetes |
| topic | Diabetes Public Health |
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