Extracellular vesicles as a next-generation drug delivery platform
Extracellular-vesicle-based cell-to-cell communication is conserved across all kingdoms of life. There is compelling evidence that extracellular vesicles are involved in major (patho)physiological processes, including cellular homoeostasis, infection propagation, cancer development and cardiovascula...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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Springer Nature
2021
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| _version_ | 1797075896794873856 |
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| author | Herrmann, IK Wood, MJA Fuhrmann, G |
| author_facet | Herrmann, IK Wood, MJA Fuhrmann, G |
| author_sort | Herrmann, IK |
| collection | OXFORD |
| description | Extracellular-vesicle-based cell-to-cell communication is conserved across all kingdoms of life. There is compelling evidence that extracellular vesicles are involved in major (patho)physiological processes, including cellular homoeostasis, infection propagation, cancer development and cardiovascular diseases. Various studies suggest that extracellular vesicles have several advantages over conventional synthetic carriers, opening new frontiers for modern drug delivery. Despite extensive research, clinical translation of extracellular-vesicle-based therapies remains challenging. Here, we discuss the uniqueness of extracellular vesicles along with critical design and development steps required to utilize their full potential as drug carriers, including loading methods, in-depth characterization and large-scale manufacturing. We compare the prospects of extracellular vesicles with those of the well established liposomes and provide guidelines to direct the process of developing vesicle-based drug delivery systems. |
| first_indexed | 2024-03-06T23:56:44Z |
| format | Journal article |
| id | oxford-uuid:74776726-e51e-4ba9-a0fa-facf3dac5ae0 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:56:44Z |
| publishDate | 2021 |
| publisher | Springer Nature |
| record_format | dspace |
| spelling | oxford-uuid:74776726-e51e-4ba9-a0fa-facf3dac5ae02022-03-26T20:03:10ZExtracellular vesicles as a next-generation drug delivery platformJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:74776726-e51e-4ba9-a0fa-facf3dac5ae0EnglishSymplectic ElementsSpringer Nature2021Herrmann, IKWood, MJAFuhrmann, GExtracellular-vesicle-based cell-to-cell communication is conserved across all kingdoms of life. There is compelling evidence that extracellular vesicles are involved in major (patho)physiological processes, including cellular homoeostasis, infection propagation, cancer development and cardiovascular diseases. Various studies suggest that extracellular vesicles have several advantages over conventional synthetic carriers, opening new frontiers for modern drug delivery. Despite extensive research, clinical translation of extracellular-vesicle-based therapies remains challenging. Here, we discuss the uniqueness of extracellular vesicles along with critical design and development steps required to utilize their full potential as drug carriers, including loading methods, in-depth characterization and large-scale manufacturing. We compare the prospects of extracellular vesicles with those of the well established liposomes and provide guidelines to direct the process of developing vesicle-based drug delivery systems. |
| spellingShingle | Herrmann, IK Wood, MJA Fuhrmann, G Extracellular vesicles as a next-generation drug delivery platform |
| title | Extracellular vesicles as a next-generation drug delivery platform |
| title_full | Extracellular vesicles as a next-generation drug delivery platform |
| title_fullStr | Extracellular vesicles as a next-generation drug delivery platform |
| title_full_unstemmed | Extracellular vesicles as a next-generation drug delivery platform |
| title_short | Extracellular vesicles as a next-generation drug delivery platform |
| title_sort | extracellular vesicles as a next generation drug delivery platform |
| work_keys_str_mv | AT herrmannik extracellularvesiclesasanextgenerationdrugdeliveryplatform AT woodmja extracellularvesiclesasanextgenerationdrugdeliveryplatform AT fuhrmanng extracellularvesiclesasanextgenerationdrugdeliveryplatform |