Mechanism of first-dose cytokine-release syndrome by CAMPATH 1-H: involvement of CD16 (FcgammaRIII) and CD11a/CD18 (LFA-1) on NK cells.

Mechanism of first-dose cytokine-release syndrome by CAMPATH 1-H: involvement of CD16 (FcgammaRIII) and CD11a/CD18 (LFA-1) on NK cells.

The administration of the immunosuppressive humanized monoclonal antibody CAMPATH 1-H, which recognizes CD52 on lymphocytes and monocytes, is associated with a first-dose cytokine-release syndrome involving TNFalpha, IFNgamma, and IL-6 clinically. In vitro models have been used to establish the cell...

Descrición completa

Detalles Bibliográficos
Main Authors: Wing, MG, Moreau, T, Greenwood, J, Smith, R, Hale, G, Isaacs, J, Waldmann, H, Lachmann, P, Compston, A
Formato: Journal article
Idioma:English
Publicado: 1996

Títulos similares

Títulos similares