Depression and tetrahydrobiopterin: the folate connection.
Total biopterin, neopterin and creatinine were measured in spot urine samples from affective disorder patients on lithium therapy and control subjects. Folic acid was also measured in plasma in a sample of the patients. The mean neopterin: biopterin ratio was significantly higher in the 76 patients...
| Glavni autori: | , , , , , |
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| Format: | Journal article |
| Jezik: | English |
| Izdano: |
1989
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| _version_ | 1826279324119990272 |
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| author | Coppen, A Swade, C Jones, SA Armstrong, R Blair, J Leeming, R |
| author_facet | Coppen, A Swade, C Jones, SA Armstrong, R Blair, J Leeming, R |
| author_sort | Coppen, A |
| collection | OXFORD |
| description | Total biopterin, neopterin and creatinine were measured in spot urine samples from affective disorder patients on lithium therapy and control subjects. Folic acid was also measured in plasma in a sample of the patients. The mean neopterin: biopterin ratio was significantly higher in the 76 patients (3.2 +/- 0.5) than in the 61 controls (1.8 +/- 0.1). In female patients biopterin levels were significantly lower than in controls. In the control groups there was a significant correlation between the molar concentration of neopterin and biopterin. No such correlation was found in the patients. These data indicate that tetrahydrobiopterin (BH4) biosynthesis is reduced in this group. A significant positive correlation was found between plasma folate and urinary biopterin. It is suggested that folate deficiency may impair the synthesis of BH4, a cofactor essential for the synthesis of 5-HT and other monoamines that are involved in the pathogenesis of affective disorders. |
| first_indexed | 2024-03-06T23:57:00Z |
| format | Journal article |
| id | oxford-uuid:7494d1ea-02d0-437b-af1e-a186e6873ed6 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:57:00Z |
| publishDate | 1989 |
| record_format | dspace |
| spelling | oxford-uuid:7494d1ea-02d0-437b-af1e-a186e6873ed62022-03-26T20:03:48ZDepression and tetrahydrobiopterin: the folate connection.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:7494d1ea-02d0-437b-af1e-a186e6873ed6EnglishSymplectic Elements at Oxford1989Coppen, ASwade, CJones, SAArmstrong, RBlair, JLeeming, RTotal biopterin, neopterin and creatinine were measured in spot urine samples from affective disorder patients on lithium therapy and control subjects. Folic acid was also measured in plasma in a sample of the patients. The mean neopterin: biopterin ratio was significantly higher in the 76 patients (3.2 +/- 0.5) than in the 61 controls (1.8 +/- 0.1). In female patients biopterin levels were significantly lower than in controls. In the control groups there was a significant correlation between the molar concentration of neopterin and biopterin. No such correlation was found in the patients. These data indicate that tetrahydrobiopterin (BH4) biosynthesis is reduced in this group. A significant positive correlation was found between plasma folate and urinary biopterin. It is suggested that folate deficiency may impair the synthesis of BH4, a cofactor essential for the synthesis of 5-HT and other monoamines that are involved in the pathogenesis of affective disorders. |
| spellingShingle | Coppen, A Swade, C Jones, SA Armstrong, R Blair, J Leeming, R Depression and tetrahydrobiopterin: the folate connection. |
| title | Depression and tetrahydrobiopterin: the folate connection. |
| title_full | Depression and tetrahydrobiopterin: the folate connection. |
| title_fullStr | Depression and tetrahydrobiopterin: the folate connection. |
| title_full_unstemmed | Depression and tetrahydrobiopterin: the folate connection. |
| title_short | Depression and tetrahydrobiopterin: the folate connection. |
| title_sort | depression and tetrahydrobiopterin the folate connection |
| work_keys_str_mv | AT coppena depressionandtetrahydrobiopterinthefolateconnection AT swadec depressionandtetrahydrobiopterinthefolateconnection AT jonessa depressionandtetrahydrobiopterinthefolateconnection AT armstrongr depressionandtetrahydrobiopterinthefolateconnection AT blairj depressionandtetrahydrobiopterinthefolateconnection AT leemingr depressionandtetrahydrobiopterinthefolateconnection |