ZBTB2 links p53 deficiency to HIF-1-mediated hypoxia signaling to promote cancer aggressiveness

ZBTB2 links p53 deficiency to HIF-1-mediated hypoxia signaling to promote cancer aggressiveness

Aberrant activation of the hypoxia-inducible transcription factor HIF-1 and dysfunction of the tumor suppressor p53 have been reported to induce malignant phenotypes and therapy resistance of cancers. However, their mechanistic and functional relationship remains largely unknown. Here, we reveal a m...

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Main Authors: Koyasu, S, Horita, S, Saito, K, Kobayashi, M, Ishikita, H, Chow, CC, Kambe, G, Nishikawa, S, Menju, T, Morinibu, A, Okochi, Y, Tabuchi, Y, Onodera, Y, Takeda, N, Date, H, Semenza, GL, Hammond, EM, Harada, H
Format: Journal article
Jezik:English
Izdano: EMBO Press 2022

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