Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer.
INTRODUCTION: Breast cancer remains a significant scientific, clinical and societal challenge. This gap analysis has reviewed and critically assessed enduring issues and new challenges emerging from recent research, and proposes strategies for translating solutions into practice. METHODS: More than...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
BioMed Central
2013
|
| _version_ | 1797075931458699264 |
|---|---|
| author | Eccles, SA Aboagye, E Ali, S Anderson, A Armes, J Berditchevski, F Blaydes, J Brennan, K Brown, N Bryant, H Bundred, N Burchell, J Campbell, A Carroll, J Clarke, R Coles, C Cook, G Cox, A Curtin, N Dekker, L Silva, I Duffy, S Easton, D Eccles, D Edwards, DR Edwards, J Evans, D Fenlon, D Flanagan, J Foster, C Gallagher, WM Garcia-Closas, M Gee, J Gescher, A Goh, V Groves, A Harvey, A Harvie, M Hennessy, B Hiscox, S Holen, I Howell, S Howell, A Hubbard, G Hulbert-Williams, N Hunter, MS Jasani, B Jones, L Key, T Kirwan, C Kong, A Kunkler, I Langdon, S Leach, M Mann, D Marshall, J Martin, L Martin, S Macdougall, J Miles, D Miller, W Morris, JR Moss, S Mullan, P Natrajan, R O'Connor, J O'Connor, R Palmieri, C Pharoah, P Rakha, E Reed, E Robinson, S Sahai, E Saxton, J Schmid, P Smalley, M Speirs, V Stein, R Stingl, J Streuli, C Tutt, A Velikova, G Walker, R Watson, C Williams, K Young, L Thompson, A |
| author_facet | Eccles, SA Aboagye, E Ali, S Anderson, A Armes, J Berditchevski, F Blaydes, J Brennan, K Brown, N Bryant, H Bundred, N Burchell, J Campbell, A Carroll, J Clarke, R Coles, C Cook, G Cox, A Curtin, N Dekker, L Silva, I Duffy, S Easton, D Eccles, D Edwards, DR Edwards, J Evans, D Fenlon, D Flanagan, J Foster, C Gallagher, WM Garcia-Closas, M Gee, J Gescher, A Goh, V Groves, A Harvey, A Harvie, M Hennessy, B Hiscox, S Holen, I Howell, S Howell, A Hubbard, G Hulbert-Williams, N Hunter, MS Jasani, B Jones, L Key, T Kirwan, C Kong, A Kunkler, I Langdon, S Leach, M Mann, D Marshall, J Martin, L Martin, S Macdougall, J Miles, D Miller, W Morris, JR Moss, S Mullan, P Natrajan, R O'Connor, J O'Connor, R Palmieri, C Pharoah, P Rakha, E Reed, E Robinson, S Sahai, E Saxton, J Schmid, P Smalley, M Speirs, V Stein, R Stingl, J Streuli, C Tutt, A Velikova, G Walker, R Watson, C Williams, K Young, L Thompson, A |
| author_sort | Eccles, SA |
| collection | OXFORD |
| description | INTRODUCTION: Breast cancer remains a significant scientific, clinical and societal challenge. This gap analysis has reviewed and critically assessed enduring issues and new challenges emerging from recent research, and proposes strategies for translating solutions into practice. METHODS: More than 100 internationally recognised specialist breast cancer scientists, clinicians and healthcare professionals collaborated to address nine thematic areas: genetics, epigenetics and epidemiology; molecular pathology and cell biology; hormonal influences and endocrine therapy; imaging, detection and screening; current/novel therapies and biomarkers; drug resistance; metastasis, angiogenesis, circulating tumour cells, cancer 'stem' cells; risk and prevention; living with and managing breast cancer and its treatment. The groups developed summary papers through an iterative process which, following further appraisal from experts and patients, were melded into this summary account. RESULTS: The 10 major gaps identified were: (1) understanding the functions and contextual interactions of genetic and epigenetic changes in normal breast development and during malignant transformation; (2) how to implement sustainable lifestyle changes (diet, exercise and weight) and chemopreventive strategies; (3) the need for tailored screening approaches including clinically actionable tests; (4) enhancing knowledge of molecular drivers behind breast cancer subtypes, progression and metastasis; (5) understanding the molecular mechanisms of tumour heterogeneity, dormancy, de novo or acquired resistance and how to target key nodes in these dynamic processes; (6) developing validated markers for chemosensitivity and radiosensitivity; (7) understanding the optimal duration, sequencing and rational combinations of treatment for improved personalised therapy; (8) validating multimodality imaging biomarkers for minimally invasive diagnosis and monitoring of responses in primary and metastatic disease; (9) developing interventions and support to improve the survivorship experience; (10) a continuing need for clinical material for translational research derived from normal breast, blood, primary, relapsed, metastatic and drug-resistant cancers with expert bioinformatics support to maximise its utility. The proposed infrastructural enablers include enhanced resources to support clinically relevant in vitro and in vivo tumour models; improved access to appropriate, fully annotated clinical samples; extended biomarker discovery, validation and standardisation; and facilitated cross-discipline working. CONCLUSIONS: With resources to conduct further high-quality targeted research focusing on the gaps identified, increased knowledge translating into improved clinical care should be achievable within five years. |
| first_indexed | 2024-03-06T23:57:11Z |
| format | Journal article |
| id | oxford-uuid:74a38e7b-a1ff-43ac-b628-b2c6e156538e |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:57:11Z |
| publishDate | 2013 |
| publisher | BioMed Central |
| record_format | dspace |
| spelling | oxford-uuid:74a38e7b-a1ff-43ac-b628-b2c6e156538e2022-03-26T20:04:29ZCritical research gaps and translational priorities for the successful prevention and treatment of breast cancer.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:74a38e7b-a1ff-43ac-b628-b2c6e156538eEnglishSymplectic Elements at OxfordBioMed Central2013Eccles, SAAboagye, EAli, SAnderson, AArmes, JBerditchevski, FBlaydes, JBrennan, KBrown, NBryant, HBundred, NBurchell, JCampbell, ACarroll, JClarke, RColes, CCook, GCox, ACurtin, NDekker, LSilva, IDuffy, SEaston, DEccles, DEdwards, DREdwards, JEvans, DFenlon, DFlanagan, JFoster, CGallagher, WMGarcia-Closas, MGee, JGescher, AGoh, VGroves, AHarvey, AHarvie, MHennessy, BHiscox, SHolen, IHowell, SHowell, AHubbard, GHulbert-Williams, NHunter, MSJasani, BJones, LKey, TKirwan, CKong, AKunkler, ILangdon, SLeach, MMann, DMarshall, JMartin, LMartin, SMacdougall, JMiles, DMiller, WMorris, JRMoss, SMullan, PNatrajan, RO'Connor, JO'Connor, RPalmieri, CPharoah, PRakha, EReed, ERobinson, SSahai, ESaxton, JSchmid, PSmalley, MSpeirs, VStein, RStingl, JStreuli, CTutt, AVelikova, GWalker, RWatson, CWilliams, KYoung, LThompson, AINTRODUCTION: Breast cancer remains a significant scientific, clinical and societal challenge. This gap analysis has reviewed and critically assessed enduring issues and new challenges emerging from recent research, and proposes strategies for translating solutions into practice. METHODS: More than 100 internationally recognised specialist breast cancer scientists, clinicians and healthcare professionals collaborated to address nine thematic areas: genetics, epigenetics and epidemiology; molecular pathology and cell biology; hormonal influences and endocrine therapy; imaging, detection and screening; current/novel therapies and biomarkers; drug resistance; metastasis, angiogenesis, circulating tumour cells, cancer 'stem' cells; risk and prevention; living with and managing breast cancer and its treatment. The groups developed summary papers through an iterative process which, following further appraisal from experts and patients, were melded into this summary account. RESULTS: The 10 major gaps identified were: (1) understanding the functions and contextual interactions of genetic and epigenetic changes in normal breast development and during malignant transformation; (2) how to implement sustainable lifestyle changes (diet, exercise and weight) and chemopreventive strategies; (3) the need for tailored screening approaches including clinically actionable tests; (4) enhancing knowledge of molecular drivers behind breast cancer subtypes, progression and metastasis; (5) understanding the molecular mechanisms of tumour heterogeneity, dormancy, de novo or acquired resistance and how to target key nodes in these dynamic processes; (6) developing validated markers for chemosensitivity and radiosensitivity; (7) understanding the optimal duration, sequencing and rational combinations of treatment for improved personalised therapy; (8) validating multimodality imaging biomarkers for minimally invasive diagnosis and monitoring of responses in primary and metastatic disease; (9) developing interventions and support to improve the survivorship experience; (10) a continuing need for clinical material for translational research derived from normal breast, blood, primary, relapsed, metastatic and drug-resistant cancers with expert bioinformatics support to maximise its utility. The proposed infrastructural enablers include enhanced resources to support clinically relevant in vitro and in vivo tumour models; improved access to appropriate, fully annotated clinical samples; extended biomarker discovery, validation and standardisation; and facilitated cross-discipline working. CONCLUSIONS: With resources to conduct further high-quality targeted research focusing on the gaps identified, increased knowledge translating into improved clinical care should be achievable within five years. |
| spellingShingle | Eccles, SA Aboagye, E Ali, S Anderson, A Armes, J Berditchevski, F Blaydes, J Brennan, K Brown, N Bryant, H Bundred, N Burchell, J Campbell, A Carroll, J Clarke, R Coles, C Cook, G Cox, A Curtin, N Dekker, L Silva, I Duffy, S Easton, D Eccles, D Edwards, DR Edwards, J Evans, D Fenlon, D Flanagan, J Foster, C Gallagher, WM Garcia-Closas, M Gee, J Gescher, A Goh, V Groves, A Harvey, A Harvie, M Hennessy, B Hiscox, S Holen, I Howell, S Howell, A Hubbard, G Hulbert-Williams, N Hunter, MS Jasani, B Jones, L Key, T Kirwan, C Kong, A Kunkler, I Langdon, S Leach, M Mann, D Marshall, J Martin, L Martin, S Macdougall, J Miles, D Miller, W Morris, JR Moss, S Mullan, P Natrajan, R O'Connor, J O'Connor, R Palmieri, C Pharoah, P Rakha, E Reed, E Robinson, S Sahai, E Saxton, J Schmid, P Smalley, M Speirs, V Stein, R Stingl, J Streuli, C Tutt, A Velikova, G Walker, R Watson, C Williams, K Young, L Thompson, A Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer. |
| title | Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer. |
| title_full | Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer. |
| title_fullStr | Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer. |
| title_full_unstemmed | Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer. |
| title_short | Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer. |
| title_sort | critical research gaps and translational priorities for the successful prevention and treatment of breast cancer |
| work_keys_str_mv | AT ecclessa criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT aboagyee criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT alis criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT andersona criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT armesj criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT berditchevskif criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT blaydesj criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT brennank criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT brownn criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT bryanth criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT bundredn criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT burchellj criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT campbella criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT carrollj criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT clarker criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT colesc criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT cookg criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT coxa criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT curtinn criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT dekkerl criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT silvai criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT duffys criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT eastond criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT ecclesd criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT edwardsdr criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT edwardsj criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT evansd criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT fenlond criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT flanaganj criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT fosterc criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT gallagherwm criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT garciaclosasm criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT geej criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT geschera criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT gohv criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT grovesa criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT harveya criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT harviem criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT hennessyb criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT hiscoxs criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT holeni criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT howells criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT howella criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT hubbardg criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT hulbertwilliamsn criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT hunterms criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT jasanib criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT jonesl criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT keyt criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT kirwanc criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT konga criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT kunkleri criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT langdons criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT leachm criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT mannd criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT marshallj criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT martinl criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT martins criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT macdougallj criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT milesd criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT millerw criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT morrisjr criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT mosss criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT mullanp criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT natrajanr criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT oconnorj criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT oconnorr criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT palmieric criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT pharoahp criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT rakhae criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT reede criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT robinsons criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT sahaie criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT saxtonj criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT schmidp criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT smalleym criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT speirsv criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT steinr criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT stinglj criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT streulic criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT tutta criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT velikovag criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT walkerr criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT watsonc criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT williamsk criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT youngl criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer AT thompsona criticalresearchgapsandtranslationalprioritiesforthesuccessfulpreventionandtreatmentofbreastcancer |