A short and efficient stereoselective synthesis of the potent 5-lipoxygenase inhibitor, CMI-977
A short and efficient synthesis of the potent 5-lipoxygenase inhibitor CMI-977 is described using as the key step a stereoselective anomeric oxygen to carbon rearrangement of an alkynyl stannane tetrahydrofuranyl ether derivative mediated by boron trifluoride etherate.
Main Authors: | Dixon, D, Ley, S, Reynolds, D, Chorghade, MS |
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Format: | Journal article |
Language: | English |
Published: |
2001
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