A short and efficient stereoselective synthesis of the potent 5-lipoxygenase inhibitor, CMI-977

A short and efficient synthesis of the potent 5-lipoxygenase inhibitor CMI-977 is described using as the key step a stereoselective anomeric oxygen to carbon rearrangement of an alkynyl stannane tetrahydrofuranyl ether derivative mediated by boron trifluoride etherate.

Dades bibliogràfiques
Autors principals: Dixon, D, Ley, S, Reynolds, D, Chorghade, MS
Format: Journal article
Idioma:English
Publicat: 2001