Paradoxical effects of a synthetic metalloproteinase inhibitor that blocks both p55 and p75 TNF receptor shedding and TNF alpha processing in RA synovial membrane cell cultures.
We have previously hypothesized that the pro-inflammatory cytokine TNF alpha has a pivotal role in the pathogenesis of rheumatoid arthritis (RA). It mediates its effects by cross-linking surface p55 TNF receptors (TNF-R), which can be proteolytically cleaved to yield soluble fragments. Upon binding...
প্রধান লেখক: | Williams, L, Gibbons, D, Gearing, A, Maini, R, Feldmann, M, Brennan, F |
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বিন্যাস: | Journal article |
ভাষা: | English |
প্রকাশিত: |
1996
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অনুরূপ উপাদানগুলি
অনুরূপ উপাদানগুলি
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Differential regulation of tumour necrosis factor receptors (TNF-R) by IL-4; upregulation of P55 and P75 TNF-R on synovial joint mononuclear cells.
অনুযায়ী: Cope, A, অন্যান্য
প্রকাশিত: (1993) -
TNF inhibitors are produced spontaneously by rheumatoid and osteoarthritic synovial joint cell cultures: evidence of feedback control of TNF action.
অনুযায়ী: Brennan, F, অন্যান্য
প্রকাশিত: (1995) -
The TNF Receptors p55 and p75 Mediate Chemotaxis of PMN Induced by
TNFα and a TNFα 36–62 Peptide
অনুযায়ী: Ø. Rekdal, অন্যান্য
প্রকাশিত: (1994-01-01) -
p55 and p75 tumor necrosis factor receptors are expressed and mediate common functions in synovial fibroblasts and other fibroblasts.
অনুযায়ী: Butler, D, অন্যান্য
প্রকাশিত: (1994) -
Effects of TNFα receptor TNF-Rp55- or TNF-Rp75- deficiency on corneal neovascularization and lymphangiogenesis in the mouse.
অনুযায়ী: Anna-Karina B Maier, অন্যান্য
প্রকাশিত: (2021-01-01)