Constrained pattern of viral evolution in acute and early HCV infection limits viral plasticity.

Constrained pattern of viral evolution in acute and early HCV infection limits viral plasticity.

Cellular immune responses during acute Hepatitis C virus (HCV) and HIV infection are a known correlate of infection outcome. Viral adaptation to these responses via mutation(s) within CD8+ T-cell epitopes allows these viruses to subvert host immune control. This study examined HCV evolution in 21 HC...

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Những tác giả chính:	Pfafferott, K, Gaudieri, S, Ulsenheimer, A, James, I, Heeg, M, Nolan, D, John, M, Rauch, A, Mallal, S, Lucas, A, Klenerman, P, Diepolder, H, Lucas, M
Định dạng:	Journal article
Ngôn ngữ:	English
Được phát hành:	Public Library of Science 2011

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