Autoimmune disease and HTLV-1 infection.
We describe two patients who presented with mixed connective tissue disease. Both had antinuclear antibodies and antibodies to the extractable nuclear antigen U1RNP, and both were found to be seropositive for HTLV-1 infection. We found no evidence of HTLV-1 infection in 20 other patients known to ha...
| Main Authors: | , , , , , , |
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| Formato: | Journal article |
| Idioma: | English |
| Publicado: |
1991
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| _version_ | 1826279375202418688 |
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| author | Bowness, P Davies, K Tosswill, J Bunn, C MacAlpine, L Weber, J Walport, M |
| author_facet | Bowness, P Davies, K Tosswill, J Bunn, C MacAlpine, L Weber, J Walport, M |
| author_sort | Bowness, P |
| collection | OXFORD |
| description | We describe two patients who presented with mixed connective tissue disease. Both had antinuclear antibodies and antibodies to the extractable nuclear antigen U1RNP, and both were found to be seropositive for HTLV-1 infection. We found no evidence of HTLV-1 infection in 20 other patients known to have antibodies to U1RNP or in 36 British and West German patients with idiopathic adult polymyositis. In addition the serum from 20 anti-HTLV-1 positive patients did not contain antinuclear antibodies or antibodies to U1RNP. We conclude that rheumatological disease is associated with HTLV-1 through geographical rather than aetiological means. |
| first_indexed | 2024-03-06T23:57:46Z |
| format | Journal article |
| id | oxford-uuid:74d671cb-d3f1-4a7f-a4ad-d13b8c7ed800 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:57:46Z |
| publishDate | 1991 |
| record_format | dspace |
| spelling | oxford-uuid:74d671cb-d3f1-4a7f-a4ad-d13b8c7ed8002022-03-26T20:05:32ZAutoimmune disease and HTLV-1 infection.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:74d671cb-d3f1-4a7f-a4ad-d13b8c7ed800EnglishSymplectic Elements at Oxford1991Bowness, PDavies, KTosswill, JBunn, CMacAlpine, LWeber, JWalport, MWe describe two patients who presented with mixed connective tissue disease. Both had antinuclear antibodies and antibodies to the extractable nuclear antigen U1RNP, and both were found to be seropositive for HTLV-1 infection. We found no evidence of HTLV-1 infection in 20 other patients known to have antibodies to U1RNP or in 36 British and West German patients with idiopathic adult polymyositis. In addition the serum from 20 anti-HTLV-1 positive patients did not contain antinuclear antibodies or antibodies to U1RNP. We conclude that rheumatological disease is associated with HTLV-1 through geographical rather than aetiological means. |
| spellingShingle | Bowness, P Davies, K Tosswill, J Bunn, C MacAlpine, L Weber, J Walport, M Autoimmune disease and HTLV-1 infection. |
| title | Autoimmune disease and HTLV-1 infection. |
| title_full | Autoimmune disease and HTLV-1 infection. |
| title_fullStr | Autoimmune disease and HTLV-1 infection. |
| title_full_unstemmed | Autoimmune disease and HTLV-1 infection. |
| title_short | Autoimmune disease and HTLV-1 infection. |
| title_sort | autoimmune disease and htlv 1 infection |
| work_keys_str_mv | AT bownessp autoimmunediseaseandhtlv1infection AT daviesk autoimmunediseaseandhtlv1infection AT tosswillj autoimmunediseaseandhtlv1infection AT bunnc autoimmunediseaseandhtlv1infection AT macalpinel autoimmunediseaseandhtlv1infection AT weberj autoimmunediseaseandhtlv1infection AT walportm autoimmunediseaseandhtlv1infection |