Oligomeric structure of proclavaminic acid amidino hydrolase: evolution of a hydrolytic enzyme in clavulanic acid biosynthesis.

During biosynthesis of the clinically used beta-lactamase inhibitor clavulanic acid, one of the three steps catalysed by clavaminic acid synthase is separated from the other two by a step catalysed by proclavaminic acid amidino hydrolase (PAH), in which the guanidino group of an intermediate is hydr...

詳細記述

書誌詳細
主要な著者: Elkins, J, Clifton, I, Hernández, H, Doan, L, Robinson, C, Schofield, C, Hewitson, K
フォーマット: Journal article
言語:English
出版事項: 2002