Fetal liver hepcidin secures iron stores in utero
In the adult, the liver-derived hormone hepcidin (HAMP) controls systemic iron levels by blocking the iron-exporting protein ferroportin (FPN) in the gut and spleen, the sites of iron absorption and recycling respectively. Impaired HAMP expression or FPN responsiveness to HAMP result in iron overloa...
Main Authors: | Kämmerer, L, Mohammad, G, Wolna, M, Robbins, P, Lakhal-Littleton, S |
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Format: | Journal article |
Language: | English |
Published: |
American Society of Hematology
2020
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