Mechanisms of transcriptional dysregulation in repeat expansion disorders.

Mechanisms of transcriptional dysregulation in repeat expansion disorders.

Approximately 40 human diseases are associated with expansion of repeat sequences. These expansions can reside within coding or non-coding parts of the genes, affecting the host gene function. The presence of such expansions results in the production of toxic RNA and/or protein or causes transcripti...

Szczegółowa specyfikacja

Opis bibliograficzny
Główni autorzy:	Groh, M, Silva, L, Gromak, N
Format:	Journal article
Język:	English
Wydane:	2014

Podobne zapisy

R-loops associated with triplet repeat expansions promote gene silencing in Friedreich ataxia and fragile X syndrome
od: Groh, M, i wsp.
Wydane: (2014)

What repeat expansion disorders can teach us about the Central Dogma
od: Wang, ET, i wsp.
Wydane: (2023)

R-loops associated with triplet repeat expansions promote gene silencing in Friedreich ataxia and fragile X syndrome.
od: Matthias Groh, i wsp.
Wydane: (2014-05-01)

Senataxin: genome guardian at the interface of transcription and neurodegeneration
od: Groh, M, i wsp.
Wydane: (2016)

New pathologic mechanisms in nucleotide repeat expansion disorders
od: C.M. Rodriguez, i wsp.
Wydane: (2019-10-01)

Molecular mechanism of Spinocerebellar Ataxia type 6: glutamine repeat disorder, channelopathy or transcriptional dysregulation. The multifaceted aspects of a single mutation.
od: Paola eGiunti, i wsp.
Wydane: (2015-02-01)

Intrinsic Disorder in Proteins with Pathogenic Repeat Expansions
od: April L. Darling, i wsp.
Wydane: (2017-11-01)

RNA/DNA hybrid interactome identifies DXH9 as a molecular player in transcriptional termination and R-loop-associated DNA damage
od: Cristini, A, i wsp.
Wydane: (2018)

Coupling Transcriptional State to Large-Scale Repeat Expansions in Yeast
od: Kartik A. Shah, i wsp.
Wydane: (2014-12-01)

A transgenic cell line with inducible transcription for studying (CGG)n repeat expansion mechanisms
od: I. V. Grishchenko, i wsp.
Wydane: (2021-03-01)

Coupling Transcriptional State to Large-Scale Repeat Expansions in Yeast
od: Shah, Kartik A., i wsp.
Wydane: (2016)

Advances in Nucleotide Repeat Expansion Diseases: Transcription Gets in Phase
od: Ana S. Figueiredo, i wsp.
Wydane: (2023-03-01)

Out of balance: R-loops in human disease
od: Groh, M, i wsp.
Wydane: (2014)

RNA Helicases in Microsatellite Repeat Expansion Disorders and Neurodegeneration
od: Lydia M. Castelli, i wsp.
Wydane: (2022-05-01)

RNA/DNA Hybrid Interactome Identifies DXH9 as a Molecular Player in Transcriptional Termination and R-Loop-Associated DNA Damage
od: Agnese Cristini, i wsp.
Wydane: (2018-05-01)

The Role of NRF2 in Trinucleotide Repeat Expansion Disorders
od: Kuo-Hsuan Chang, i wsp.
Wydane: (2024-05-01)

Canine Lafora Disease: An Unstable Repeat Expansion Disorder
od: Thilo von Klopmann, i wsp.
Wydane: (2021-07-01)

Increased global transcription activity as a mechanism of replication stress in cancer
od: Kotsantis, P, i wsp.
Wydane: (2016)

SOSS-INTAC: a new gatekeeper of genomic integrity at the interface of transcription and R-loops
od: Gromak, N
Wydane: (2023)

Gene–Environment Interactions in Repeat Expansion Diseases: Mechanisms of Environmentally Induced Repeat Instability
od: Stephanie Calluori, i wsp.
Wydane: (2023-02-01)

Repeat-mediated epigenetic dysregulation of the FMR1 gene in the Fragile X-related disorders
od: Karen eUsdin, i wsp.
Wydane: (2015-06-01)

Human 5' --> 3' exonuclease Xrn2 promotes transcription termination at co-transcriptional cleavage sites.
od: West, S, i wsp.
Wydane: (2004)

Repeated evolution of circadian clock dysregulation in cavefish populations.
od: Katya L Mack, i wsp.
Wydane: (2021-07-01)

Transcriptional Dysregulation of MYC Reveals Common Enhancer-Docking Mechanism
od: Jurian Schuijers, i wsp.
Wydane: (2018-04-01)

Transcriptional Dysregulation of MYC Reveals Common Enhancer-Docking Mechanism
od: Schuijers, Jurian, i wsp.
Wydane: (2018)

Out of balance: R-loops in human disease.
od: Matthias Groh, i wsp.
Wydane: (2014-09-01)

Exon tethering in transcription by RNA polymerase II.
od: Dye, M, i wsp.
Wydane: (2006)

Transcriptional dysregulation and impairment of PHOX2B auto-regulatory mechanism induced by polyalanine expansion mutations associated with congenital central hypoventilation syndrome
od: Simona Di Lascio, i wsp.
Wydane: (2013-02-01)

Detection of expanded CAG repeats in Bipolar Affective Disorder using the repeat expansion detection (RED) method
od: Kerstin Lindblad, i wsp.
Wydane: (1995-02-01)

P635: Long read sequencing for the analysis of repeat expansion disorders
od: April Berlyoung, i wsp.
Wydane: (2024-01-01)

Pause sites promote transcriptional termination of mammalian RNA polymerase II.
od: Gromak, N, i wsp.
Wydane: (2006)

Primary microRNA transcripts are processed co-transcriptionally.
od: Morlando, M, i wsp.
Wydane: (2008)

Primary microRNA transcripts are processed co-transcriptionally.
od: Morlando, M, i wsp.
Wydane: (2008)

Dysregulation of PGC-1α-Dependent Transcriptional Programs in Neurological and Developmental Disorders: Therapeutic Challenges and Opportunities
od: Laura J. McMeekin, i wsp.
Wydane: (2021-02-01)

Evidence for transcriptional factor dysregulation in the dorsal raphe nucleus of patients with major depressive disorder
od: Ilan A Kerman, i wsp.
Wydane: (2012-10-01)

The power expansions of the solutions of the first painlevé hierarchy
od: A. A. Grigor'ev, i wsp.
Wydane: (2006-12-01)

Unusual structures of CCTG repeats and their participation in repeat expansion
od: Guo Pei, i wsp.
Wydane: (2016-12-01)

Transcription factor 3 is dysregulated in megakaryocytes in myelofibrosis
od: Ryan J Collinson, i wsp.
Wydane: (2024-12-01)

Expansion of protein domain repeats.
od: Asa K Björklund, i wsp.
Wydane: (2006-08-01)

Transcription-dependent DNA double-strand breaks and human disease
od: Cristini, A, i wsp.
Wydane: (2020)