Mechanisms of transcriptional dysregulation in repeat expansion disorders.

Approximately 40 human diseases are associated with expansion of repeat sequences. These expansions can reside within coding or non-coding parts of the genes, affecting the host gene function. The presence of such expansions results in the production of toxic RNA and/or protein or causes transcripti...

Täydet tiedot

Bibliografiset tiedot
Päätekijät: Groh, M, Silva, L, Gromak, N
Aineistotyyppi: Journal article
Kieli:English
Julkaistu: 2014