Ejection of structural zinc leads to inhibition of γ-butyrobetaine hydroxylase.
γ-Butyrobetaine hydroxylase (BBOX) is a 2-oxoglutarate and Fe(II) dependent oxygenase that catalyses an essential step during carnitine biosynthesis in animals. BBOX is inhibited by ejection of structural zinc by a set of selenium containing analogues. Previous structural analyses indicated that an...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Sprog: | English |
| Udgivet: |
2014
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