Effects of chronic hyperglycaemia on pancreatic β-cell metabolism and insulin biosynthesis
<p>Chronic hyperglycaemia severely impairs the coupling between pancreatic β-cell glucose metabolism and insulin secretion that forms an essential part of blood glucose homeostasis. This thesis focuses on two effects of hyperglycaemia-induced alterations in β-cell metabolism: a decline in insu...
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| Format: | Thesis |
| Language: | English |
| Published: |
2023
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