Synthesis and assessment of [11C]acetylhomotaurine as an imaging agent for the study of the pharmacodynamic properties of acamprosate by positron emission tomography.
Acetylhomotaurine was labeled with (11)C via N-acetylation with [(11)C]acetyl chloride. The synthesis yielded 48.2+/-3.8%, decay corrected to end of bombardment. The specific activity of the (radio)chemically pure product was 20.8+/-2.0 GBq/micromol at EOS. In vivo studies revealed a very fast clear...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2004
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| _version_ | 1797076115625345024 |
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| author | Courtyn, J Cornelissen, B Oltenfreiter, R Vandecapelle, M Slegers, G Strijckmans, K |
| author_facet | Courtyn, J Cornelissen, B Oltenfreiter, R Vandecapelle, M Slegers, G Strijckmans, K |
| author_sort | Courtyn, J |
| collection | OXFORD |
| description | Acetylhomotaurine was labeled with (11)C via N-acetylation with [(11)C]acetyl chloride. The synthesis yielded 48.2+/-3.8%, decay corrected to end of bombardment. The specific activity of the (radio)chemically pure product was 20.8+/-2.0 GBq/micromol at EOS. In vivo studies revealed a very fast clearance of the tracer from the blood and a uniform distribution in the different brain regions. Unfortunately, the poor passage through the blood brain barrier makes the tracer not suitable for PET studies. |
| first_indexed | 2024-03-06T23:59:35Z |
| format | Journal article |
| id | oxford-uuid:7574d68f-89de-4d08-b7a7-5b984f3e6e8e |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:59:35Z |
| publishDate | 2004 |
| record_format | dspace |
| spelling | oxford-uuid:7574d68f-89de-4d08-b7a7-5b984f3e6e8e2022-03-26T20:09:28ZSynthesis and assessment of [11C]acetylhomotaurine as an imaging agent for the study of the pharmacodynamic properties of acamprosate by positron emission tomography.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:7574d68f-89de-4d08-b7a7-5b984f3e6e8eEnglishSymplectic Elements at Oxford2004Courtyn, JCornelissen, BOltenfreiter, RVandecapelle, MSlegers, GStrijckmans, KAcetylhomotaurine was labeled with (11)C via N-acetylation with [(11)C]acetyl chloride. The synthesis yielded 48.2+/-3.8%, decay corrected to end of bombardment. The specific activity of the (radio)chemically pure product was 20.8+/-2.0 GBq/micromol at EOS. In vivo studies revealed a very fast clearance of the tracer from the blood and a uniform distribution in the different brain regions. Unfortunately, the poor passage through the blood brain barrier makes the tracer not suitable for PET studies. |
| spellingShingle | Courtyn, J Cornelissen, B Oltenfreiter, R Vandecapelle, M Slegers, G Strijckmans, K Synthesis and assessment of [11C]acetylhomotaurine as an imaging agent for the study of the pharmacodynamic properties of acamprosate by positron emission tomography. |
| title | Synthesis and assessment of [11C]acetylhomotaurine as an imaging agent for the study of the pharmacodynamic properties of acamprosate by positron emission tomography. |
| title_full | Synthesis and assessment of [11C]acetylhomotaurine as an imaging agent for the study of the pharmacodynamic properties of acamprosate by positron emission tomography. |
| title_fullStr | Synthesis and assessment of [11C]acetylhomotaurine as an imaging agent for the study of the pharmacodynamic properties of acamprosate by positron emission tomography. |
| title_full_unstemmed | Synthesis and assessment of [11C]acetylhomotaurine as an imaging agent for the study of the pharmacodynamic properties of acamprosate by positron emission tomography. |
| title_short | Synthesis and assessment of [11C]acetylhomotaurine as an imaging agent for the study of the pharmacodynamic properties of acamprosate by positron emission tomography. |
| title_sort | synthesis and assessment of 11c acetylhomotaurine as an imaging agent for the study of the pharmacodynamic properties of acamprosate by positron emission tomography |
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