Synthesis and assessment of [11C]acetylhomotaurine as an imaging agent for the study of the pharmacodynamic properties of acamprosate by positron emission tomography.
Acetylhomotaurine was labeled with (11)C via N-acetylation with [(11)C]acetyl chloride. The synthesis yielded 48.2+/-3.8%, decay corrected to end of bombardment. The specific activity of the (radio)chemically pure product was 20.8+/-2.0 GBq/micromol at EOS. In vivo studies revealed a very fast clear...
Main Authors: | Courtyn, J, Cornelissen, B, Oltenfreiter, R, Vandecapelle, M, Slegers, G, Strijckmans, K |
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Format: | Journal article |
Language: | English |
Published: |
2004
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