Heterogeneity of tumour response to hypoxia: carbonic anhydrase IX induction defines a subpopulation of hypoxic cells with stem cell properties and drug resistance

Heterogeneity of tumour response to hypoxia: carbonic anhydrase IX induction defines a subpopulation of hypoxic cells with stem cell properties and drug resistance

<p>Carbonic anhydrase IX (CA9) is strongly induced by hypoxia and its overexpression is associated with poor therapeutic outcome in cancer. The function of CAIX is to catalyze the reversible hydration of CO2 to bicarbonate and a proton. This helps hypoxic tumours to maintain a more neutral int...

書誌詳細
第一著者:	Ledaki, I
その他の著者:	Harris, A
フォーマット:	学位論文
言語:	English
出版事項:	2013
主題:	Tumour pathology Biology Biology (medical sciences) Cell Biology (see also Plant sciences) Oncology Tumours

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