Scale-up of stirring as foam disruption (SAFD) to industrial scale.
Foam disruption by agitation-the stirring as foam disruption (SAFD) technique-was scaled up to pilot and production scale using Rushton turbines and an up-pumping hydrofoil impeller, the Scaba 3SHP1. The dominating mechanism behind SAFD-foam entrainment-was also demonstrated at production scale. The...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2003
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| _version_ | 1826279507492864000 |
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| author | Hoeks, F Boon, L Studer, F Wolff, M van der Schot, F Vrabél, P van der Lans, R Bujalski, W Manelius, A Blomsten, G Hjorth, S Prada, G Luyben, K Nienow, A |
| author_facet | Hoeks, F Boon, L Studer, F Wolff, M van der Schot, F Vrabél, P van der Lans, R Bujalski, W Manelius, A Blomsten, G Hjorth, S Prada, G Luyben, K Nienow, A |
| author_sort | Hoeks, F |
| collection | OXFORD |
| description | Foam disruption by agitation-the stirring as foam disruption (SAFD) technique-was scaled up to pilot and production scale using Rushton turbines and an up-pumping hydrofoil impeller, the Scaba 3SHP1. The dominating mechanism behind SAFD-foam entrainment-was also demonstrated at production scale. The mechanistic model for SAFD defines a fictitious liquid velocity generated by the (upper) impeller near the dispersion surface, which is correlated with complete foam disruption. This model proved to be scalable, thus enabling the model to be used for the design of SAFD applications. Axial upward pumping impellers appeared to be more effective with respect to SAFD than Rushton turbines, as demonstrated by retrofitting a 12,000 l bioreactor, i.e. the triple Rushton configuration was compared with a mixed impeller configuration from Scaba with a 20% lower ungassed power draw. The retrofitted impeller configuration allowed 10% more broth without risking excessive foaming. In this way a substantial increase in the volumetric productivity of the bioreactor was achieved. Design recommendations for the application of SAFD are given in this paper. Using these recommendations for the design of a 30,000 l scale bioreactor, almost foamless Escherichia coli fermentations were realised. |
| first_indexed | 2024-03-06T23:59:46Z |
| format | Journal article |
| id | oxford-uuid:75840c5c-4bca-40c6-92a1-c18b80ac6b01 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:59:46Z |
| publishDate | 2003 |
| record_format | dspace |
| spelling | oxford-uuid:75840c5c-4bca-40c6-92a1-c18b80ac6b012022-03-26T20:09:53ZScale-up of stirring as foam disruption (SAFD) to industrial scale.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:75840c5c-4bca-40c6-92a1-c18b80ac6b01EnglishSymplectic Elements at Oxford2003Hoeks, FBoon, LStuder, FWolff, Mvan der Schot, FVrabél, Pvan der Lans, RBujalski, WManelius, ABlomsten, GHjorth, SPrada, GLuyben, KNienow, AFoam disruption by agitation-the stirring as foam disruption (SAFD) technique-was scaled up to pilot and production scale using Rushton turbines and an up-pumping hydrofoil impeller, the Scaba 3SHP1. The dominating mechanism behind SAFD-foam entrainment-was also demonstrated at production scale. The mechanistic model for SAFD defines a fictitious liquid velocity generated by the (upper) impeller near the dispersion surface, which is correlated with complete foam disruption. This model proved to be scalable, thus enabling the model to be used for the design of SAFD applications. Axial upward pumping impellers appeared to be more effective with respect to SAFD than Rushton turbines, as demonstrated by retrofitting a 12,000 l bioreactor, i.e. the triple Rushton configuration was compared with a mixed impeller configuration from Scaba with a 20% lower ungassed power draw. The retrofitted impeller configuration allowed 10% more broth without risking excessive foaming. In this way a substantial increase in the volumetric productivity of the bioreactor was achieved. Design recommendations for the application of SAFD are given in this paper. Using these recommendations for the design of a 30,000 l scale bioreactor, almost foamless Escherichia coli fermentations were realised. |
| spellingShingle | Hoeks, F Boon, L Studer, F Wolff, M van der Schot, F Vrabél, P van der Lans, R Bujalski, W Manelius, A Blomsten, G Hjorth, S Prada, G Luyben, K Nienow, A Scale-up of stirring as foam disruption (SAFD) to industrial scale. |
| title | Scale-up of stirring as foam disruption (SAFD) to industrial scale. |
| title_full | Scale-up of stirring as foam disruption (SAFD) to industrial scale. |
| title_fullStr | Scale-up of stirring as foam disruption (SAFD) to industrial scale. |
| title_full_unstemmed | Scale-up of stirring as foam disruption (SAFD) to industrial scale. |
| title_short | Scale-up of stirring as foam disruption (SAFD) to industrial scale. |
| title_sort | scale up of stirring as foam disruption safd to industrial scale |
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