Single nucleotide polymorphisms in the NOD2/CARD15 gene are associated with an increased risk of relapse and death for patients with acute leukemia after hematopoietic stem-cell transplantation with unrelated donors.
PURPOSE: Hematopoietic stem cell transplantation (HSCT) is an important option in the management of acute leukemia, but the risk of disease relapse and death remains appreciable. Recent studies have suggested that nucleotide-binding oligomerization domain 2 (NOD2)/caspase recruitment domain 15 (CARD...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2007
|
| _version_ | 1797076148195164160 |
|---|---|
| author | Mayor, N Shaw, B Hughes, D Maldonado-Torres, H Madrigal, J Keshav, S Marsh, S |
| author_facet | Mayor, N Shaw, B Hughes, D Maldonado-Torres, H Madrigal, J Keshav, S Marsh, S |
| author_sort | Mayor, N |
| collection | OXFORD |
| description | PURPOSE: Hematopoietic stem cell transplantation (HSCT) is an important option in the management of acute leukemia, but the risk of disease relapse and death remains appreciable. Recent studies have suggested that nucleotide-binding oligomerization domain 2 (NOD2)/caspase recruitment domain 15 (CARD15) gene single nucleotide polymorphisms (SNPs), implicated in innate immunity and Crohn's disease, may also affect immune function post-HSCT. PATIENTS AND METHODS: NOD2/CARD15 genotypes were analyzed in 196 patients diagnosed with acute leukemia and their unrelated donors. The pairs are part of a previously well-characterized cohort with a median follow-up of 2.2 years (range, 0.42 to 6.61 years). T-cell depletion was used in 83% of pairs. RESULTS: NOD2/CARD15 SNPs were associated with a reduction in overall survival (44% v 22%; log-rank P = .0087) due to an increase in disease relapse (32% v 54%; Gray's test P = .001) as compared with wild-type pairs. In multivariate analyses, the two most significant factors impacting outcome were transplantation in relapse and the presence of SNPs. The incidence of acute graft-versus-host disease was low and there was no significant difference due to the presence of SNPs. CONCLUSION: These data indicate an unrecognized role for the NOD2/CARD15 gene in unrelated donor HSCT for acute leukemia. The increased risk of disease relapse suggests that the wild-type gene product may contribute to a graft-versus-leukemia effect. These data suggest that NOD2/CARD15 genotyping before transplantation may contribute to prognosis and influence clinical management. |
| first_indexed | 2024-03-07T00:00:04Z |
| format | Journal article |
| id | oxford-uuid:759fc08a-c89a-4e5d-b67f-ea507d285284 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:00:04Z |
| publishDate | 2007 |
| record_format | dspace |
| spelling | oxford-uuid:759fc08a-c89a-4e5d-b67f-ea507d2852842022-03-26T20:10:34ZSingle nucleotide polymorphisms in the NOD2/CARD15 gene are associated with an increased risk of relapse and death for patients with acute leukemia after hematopoietic stem-cell transplantation with unrelated donors.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:759fc08a-c89a-4e5d-b67f-ea507d285284EnglishSymplectic Elements at Oxford2007Mayor, NShaw, BHughes, DMaldonado-Torres, HMadrigal, JKeshav, SMarsh, SPURPOSE: Hematopoietic stem cell transplantation (HSCT) is an important option in the management of acute leukemia, but the risk of disease relapse and death remains appreciable. Recent studies have suggested that nucleotide-binding oligomerization domain 2 (NOD2)/caspase recruitment domain 15 (CARD15) gene single nucleotide polymorphisms (SNPs), implicated in innate immunity and Crohn's disease, may also affect immune function post-HSCT. PATIENTS AND METHODS: NOD2/CARD15 genotypes were analyzed in 196 patients diagnosed with acute leukemia and their unrelated donors. The pairs are part of a previously well-characterized cohort with a median follow-up of 2.2 years (range, 0.42 to 6.61 years). T-cell depletion was used in 83% of pairs. RESULTS: NOD2/CARD15 SNPs were associated with a reduction in overall survival (44% v 22%; log-rank P = .0087) due to an increase in disease relapse (32% v 54%; Gray's test P = .001) as compared with wild-type pairs. In multivariate analyses, the two most significant factors impacting outcome were transplantation in relapse and the presence of SNPs. The incidence of acute graft-versus-host disease was low and there was no significant difference due to the presence of SNPs. CONCLUSION: These data indicate an unrecognized role for the NOD2/CARD15 gene in unrelated donor HSCT for acute leukemia. The increased risk of disease relapse suggests that the wild-type gene product may contribute to a graft-versus-leukemia effect. These data suggest that NOD2/CARD15 genotyping before transplantation may contribute to prognosis and influence clinical management. |
| spellingShingle | Mayor, N Shaw, B Hughes, D Maldonado-Torres, H Madrigal, J Keshav, S Marsh, S Single nucleotide polymorphisms in the NOD2/CARD15 gene are associated with an increased risk of relapse and death for patients with acute leukemia after hematopoietic stem-cell transplantation with unrelated donors. |
| title | Single nucleotide polymorphisms in the NOD2/CARD15 gene are associated with an increased risk of relapse and death for patients with acute leukemia after hematopoietic stem-cell transplantation with unrelated donors. |
| title_full | Single nucleotide polymorphisms in the NOD2/CARD15 gene are associated with an increased risk of relapse and death for patients with acute leukemia after hematopoietic stem-cell transplantation with unrelated donors. |
| title_fullStr | Single nucleotide polymorphisms in the NOD2/CARD15 gene are associated with an increased risk of relapse and death for patients with acute leukemia after hematopoietic stem-cell transplantation with unrelated donors. |
| title_full_unstemmed | Single nucleotide polymorphisms in the NOD2/CARD15 gene are associated with an increased risk of relapse and death for patients with acute leukemia after hematopoietic stem-cell transplantation with unrelated donors. |
| title_short | Single nucleotide polymorphisms in the NOD2/CARD15 gene are associated with an increased risk of relapse and death for patients with acute leukemia after hematopoietic stem-cell transplantation with unrelated donors. |
| title_sort | single nucleotide polymorphisms in the nod2 card15 gene are associated with an increased risk of relapse and death for patients with acute leukemia after hematopoietic stem cell transplantation with unrelated donors |
| work_keys_str_mv | AT mayorn singlenucleotidepolymorphismsinthenod2card15geneareassociatedwithanincreasedriskofrelapseanddeathforpatientswithacuteleukemiaafterhematopoieticstemcelltransplantationwithunrelateddonors AT shawb singlenucleotidepolymorphismsinthenod2card15geneareassociatedwithanincreasedriskofrelapseanddeathforpatientswithacuteleukemiaafterhematopoieticstemcelltransplantationwithunrelateddonors AT hughesd singlenucleotidepolymorphismsinthenod2card15geneareassociatedwithanincreasedriskofrelapseanddeathforpatientswithacuteleukemiaafterhematopoieticstemcelltransplantationwithunrelateddonors AT maldonadotorresh singlenucleotidepolymorphismsinthenod2card15geneareassociatedwithanincreasedriskofrelapseanddeathforpatientswithacuteleukemiaafterhematopoieticstemcelltransplantationwithunrelateddonors AT madrigalj singlenucleotidepolymorphismsinthenod2card15geneareassociatedwithanincreasedriskofrelapseanddeathforpatientswithacuteleukemiaafterhematopoieticstemcelltransplantationwithunrelateddonors AT keshavs singlenucleotidepolymorphismsinthenod2card15geneareassociatedwithanincreasedriskofrelapseanddeathforpatientswithacuteleukemiaafterhematopoieticstemcelltransplantationwithunrelateddonors AT marshs singlenucleotidepolymorphismsinthenod2card15geneareassociatedwithanincreasedriskofrelapseanddeathforpatientswithacuteleukemiaafterhematopoieticstemcelltransplantationwithunrelateddonors |