An AKAP-Lbc-RhoA interaction inhibitor promotes the translocation of aquaporin-2 to the plasma membrane of renal collecting duct principal cells.

An AKAP-Lbc-RhoA interaction inhibitor promotes the translocation of aquaporin-2 to the plasma membrane of renal collecting duct principal cells.

Stimulation of renal collecting duct principal cells with antidiuretic hormone (arginine-vasopressin, AVP) results in inhibition of the small GTPase RhoA and the enrichment of the water channel aquaporin-2 (AQP2) in the plasma membrane. The membrane insertion facilitates water reabsorption from prim...

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Main Authors: Schrade, K, Tröger, J, Eldahshan, A, Zühlke, K, Abdul Azeez, K, Elkins, J, Neuenschwander, M, Oder, A, Elkewedi, M, Jaksch, S, Andrae, K, Li, J, Fernandes, J, Müller, P, Grunwald, S, Marino, S, Vukićević, T, Eichhorst, J, Wiesner, B, Weber, M, Kapiloff, M, Rocks, O, Daumke, O, Wieland, T, Knapp, S, von Kries, J, Klussmann, E
Format: Journal article
Language:English
Published: Public Library of Science 2018

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