Replication catastrophe induced by cyclic hypoxia leads to increased APOBEC3B activity
<p>Regions of low oxygen (hypoxia) occur in most human solid tumours and correlate with a poor patient prognosis as hypoxic regions are resistant to most cancer therapies and have an increased metastatic potential. Hypoxia is a highly dynamic state, characterised by oxygen fluctuations on the...
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| Format: | Thesis |
| Language: | English |
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2020
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