Reduced global cooperativity is a common feature underlying the amyloidogenicity of pathogenic lysozyme mutations.

One of the 20 or so human amyloid diseases is associated with the deposition in vital organs of full-length mutational variants of the antibacterial protein lysozyme. Here, we report experimental data that permit a detailed comparison to be made of the behaviour of two of these amyloidogenic variant...

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Hlavní autoři:	Dumoulin, M, Canet, D, Last, A, Pardon, E, Archer, D, Muyldermans, S, Wyns, L, Matagne, A, Robinson, C, Redfield, C, Dobson, C
Médium:	Journal article
Jazyk:	English
Vydáno:	2005

Reduced global cooperativity is a common feature underlying the amyloidogenicity of pathogenic lysozyme mutations.

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