Heritability of variation in glycaemic response to metformin: a genome-wide complex trait analysis.

Heritability of variation in glycaemic response to metformin: a genome-wide complex trait analysis.

Afficher d'autres versions (1)

BACKGROUND: Metformin is a first-line oral agent used in the treatment of type 2 diabetes, but glycaemic response to this drug is highly variable. Understanding the genetic contribution to metformin response might increase the possibility of personalising metformin treatment. We aimed to establish t...

Description complète

Détails bibliographiques
Auteurs principaux:	Zhou, K, Donnelly, L, Yang, J, Li, M, Deshmukh, H, Van Zuydam, N, Ahlqvist, E, Spencer, C, Groop, L, Morris, A, Colhoun, H, Sham, P, McCarthy, M, Palmer, C, Pearson, E
Format:	Journal article
Langue:	English
Publié:	2014

Documents similaires

Heritability of variation in glycaemic response to metformin: A genome-wide complex trait analysis
par: Zhou, K, et autres
Publié: (2014)

Estimating heritability of glycaemic response to metformin using nationwide electronic health records and population-sized pedigree
par: Iris N. Kalka, et autres
Publié: (2021-12-01)

Variation in the glucose transporter gene SLC2A2 is associated with glycaemic response to metformin
par: Kaixin, Z, et autres
Publié: (2016)

Common nonsynonymous substitutions in SLCO1B1 predispose to statin intolerance in routinely treated individuals with Type 2 diabetes: A Go-DARTS study
par: Donnelly, L, et autres
Publié: (2011)

Common nonsynonymous substitutions in SLCO1B1 predispose to statin intolerance in routinely treated individuals with type 2 diabetes: a go-DARTS study.
par: Donnelly, L, et autres
Publié: (2011)

Genome-wide association study of peripheral artery disease
par: van Zuydam, NR, et autres
Publié: (2021)

Reduced-function SLC22A1 polymorphisms encoding organic cation transporter 1 and glycemic response to metformin: a GoDARTS study.
par: Zhou, K, et autres
Publié: (2009)

The role of ATM in response to metformin treatment and activation of AMPK.
par: Zhou, K, et autres
Publié: (2012)

Towards a Region-Wide Glycaemic Management System: Strategies and Applications for Glycaemic Management of Patients with Diabetes During Hospitalisation
par: He M, et autres
Publié: (2024-09-01)

Metformin Pharmacogenetics and SLC2A2: Genome-Wide Association Study and 2-stage replication in GoDARTS and UKPDS
par: Zhou, K, et autres
Publié: (2013)

Massively expedited genome-wide heritability analysis (MEGHA)
par: Ge, Tian, et autres
Publié: (2015)

Pharmacogenetics in Type 2 diabetes: variation in TCF7L2 influences response to sulphonylureas
par: Pearson, E, et autres
Publié: (2007)

Large-scale genome-wide association meta-analysis of the 1000 genomes project imputed data identifies novel susceptibility loci for glycaemic and obesity traits
par: Horikoshi, M, et autres
Publié: (2013)

The Genetic Landscape of Renal Complications in Type 1 Diabetes
par: Sandholm, N, et autres
Publié: (2016)

A gene variant near ATM is significantly associated with metformin treatment response in type 2 diabetes: a replication and meta-analysis of two Dutch and two UK cohorts
par: 't Hart, L, et autres
Publié: (2011)

Effects of TCF7L2 rs7903146 variant on metformin response in patients with type 2 diabetes
par: Tanja Dujic, et autres
Publié: (2019-11-01)

Dietary glycaemic index and glycaemic load in the European Prospective Investigation into Cancer and Nutrition.
par: Bakel, v, et autres
Publié: (2009)

Glycaemic Control after Metformin Discontinuation in Diabetic Patients with a Declining Renal Function
par: Theresa Leyco, et autres
Publié: (2017-01-01)

A gene variant near ATM is significantly associated with metformin treatment response in type 2 diabetes: a replication and meta-analysis of five cohorts
par: van Leeuwen, N, et autres
Publié: (2012)

A gene variant near ATM is significantly associated with metformin treatment response in type 2 diabetes: a replication and meta-analysis of five cohorts.
par: van Leeuwen, N, et autres
Publié: (2012)

Heritability in the genome-wide association era
par: Zaitlen, Noah, et autres
Publié: (2017)

Gene expression profiling in skeletal muscle of subjects with different glycaemic tolerance.
par: Lindgren, C, et autres
Publié: (2001)

Glycaemic index and glycaemic load values of commonly consumed foods in the United Arab Emirates.
par: Al Dhaheri, A, et autres
Publié: (2017)

Role of Metformin Monotherapy Vs Metformin Plus Dapagliflozin in New Onset T2DM Among 40 Plus Obese Women in Glycaemic Control
par: Amarjeet Singh, et autres
Publié: (2024-10-01)

Finding the missing heritability of complex diseases.
par: Manolio, T, et autres
Publié: (2009)

Phenome-wide heritability analysis of the UK Biobank
par: Ge, Tian, et autres
Publié: (2017)

Phenome-wide heritability analysis of the UK Biobank.
par: Tian Ge, et autres
Publié: (2017-04-01)

Variation in TCF7L2 influences therapeutic response to sulfonylureas: a GoDARTs study.
par: Pearson, E, et autres
Publié: (2007)

Using genome-wide complex trait analysis to quantify 'missing heritability' in Parkinson's disease.
par: Keller, M, et autres
Publié: (2012)

Risk of anaemia with long-term metformin use in a community setting
par: Donnelly, L, et autres
Publié: (2017)

A Genome-wide Association Study Provides Evidence of Sex-specific Involvement of Chr1p35.1 (ZSCAN20-TLR12P) and Chr8p23.1 (HMGB1P46) With Diabetic Neuropathic Pain
par: Weihua Meng, et autres
Publié: (2015-10-01)

Correction: Phenome-wide heritability analysis of the UK Biobank.
par: Tian Ge, et autres
Publié: (2018-02-01)

A novel rare CUBN variant and three additional genes identified in Europeans with and without diabetes: results from an exome-wide association study of albuminuria
par: Ahluwalia, T, et autres
Publié: (2018)

Genome-wide associations for birth weight and correlations with adult disease
par: Horikoshi, M, et autres
Publié: (2016)

Glycaemic index and glycaemic load of foods and food products in Malaysia: a review
par: Osman, M. H., et autres
Publié: (2021)

Heritability estimates for 361 blood metabolites across 40 genome-wide association studies
par: Hagenbeek, F, et autres
Publié: (2020)

Identification of biomarkers for glycaemic deterioration in type 2 diabetes
par: Slieker, Roderick C., et autres
Publié: (2023)

Identification of biomarkers for glycaemic deterioration in type 2 diabetes
par: Roderick C. Slieker, et autres
Publié: (2023-05-01)

The impact of cardiovascular co-morbidities and duration of diabetes on the association between microvascular function and glycaemic control
par: F. Casanova, et autres
Publié: (2017-09-01)

Effect of glycaemic control and the introduction of insulin therapy on retinopathy in non-insulin-dependent diabetes mellitus [2] (multiple letters)
par: Stratton, I, et autres
Publié: (1997)