Multiple independent introductions of Plasmodium falciparum in South America.
The origin of Plasmodium falciparum in South America is controversial. Some studies suggest a recent introduction during the European colonizations and the transatlantic slave trade. Other evidence--archeological and genetic--suggests a much older origin. We collected and analyzed P. falciparum isol...
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Sprache: | English |
| Veröffentlicht: |
2012
|
| _version_ | 1826279648182403072 |
|---|---|
| author | Yalcindag, E Elguero, E Arnathau, C Durand, P Akiana, J Anderson, T Aubouy, A Balloux, F Besnard, P Bogreau, H Carnevale, P D'Alessandro, U Fontenille, D Gamboa, D Jombart, T Le Mire, J Leroy, E Maestre, A Mayxay, M Ménard, D Musset, L Newton, P Nkoghé, D Noya, O Ollomo, B |
| author_facet | Yalcindag, E Elguero, E Arnathau, C Durand, P Akiana, J Anderson, T Aubouy, A Balloux, F Besnard, P Bogreau, H Carnevale, P D'Alessandro, U Fontenille, D Gamboa, D Jombart, T Le Mire, J Leroy, E Maestre, A Mayxay, M Ménard, D Musset, L Newton, P Nkoghé, D Noya, O Ollomo, B |
| author_sort | Yalcindag, E |
| collection | OXFORD |
| description | The origin of Plasmodium falciparum in South America is controversial. Some studies suggest a recent introduction during the European colonizations and the transatlantic slave trade. Other evidence--archeological and genetic--suggests a much older origin. We collected and analyzed P. falciparum isolates from different regions of the world, encompassing the distribution range of the parasite, including populations from sub-Saharan Africa, the Middle East, Southeast Asia, and South America. Analyses of microsatellite and SNP polymorphisms show that the populations of P. falciparum in South America are subdivided in two main genetic clusters (northern and southern). Phylogenetic analyses, as well as Approximate Bayesian Computation methods suggest independent introductions of the two clusters from African sources. Our estimates of divergence time between the South American populations and their likely sources favor a likely introduction from Africa during the transatlantic slave trade. |
| first_indexed | 2024-03-07T00:01:54Z |
| format | Journal article |
| id | oxford-uuid:763e90dc-85aa-42a5-bf49-62e1261b93e3 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:01:54Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | oxford-uuid:763e90dc-85aa-42a5-bf49-62e1261b93e32022-03-26T20:14:28ZMultiple independent introductions of Plasmodium falciparum in South America.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:763e90dc-85aa-42a5-bf49-62e1261b93e3EnglishSymplectic Elements at Oxford2012Yalcindag, EElguero, EArnathau, CDurand, PAkiana, JAnderson, TAubouy, ABalloux, FBesnard, PBogreau, HCarnevale, PD'Alessandro, UFontenille, DGamboa, DJombart, TLe Mire, JLeroy, EMaestre, AMayxay, MMénard, DMusset, LNewton, PNkoghé, DNoya, OOllomo, BThe origin of Plasmodium falciparum in South America is controversial. Some studies suggest a recent introduction during the European colonizations and the transatlantic slave trade. Other evidence--archeological and genetic--suggests a much older origin. We collected and analyzed P. falciparum isolates from different regions of the world, encompassing the distribution range of the parasite, including populations from sub-Saharan Africa, the Middle East, Southeast Asia, and South America. Analyses of microsatellite and SNP polymorphisms show that the populations of P. falciparum in South America are subdivided in two main genetic clusters (northern and southern). Phylogenetic analyses, as well as Approximate Bayesian Computation methods suggest independent introductions of the two clusters from African sources. Our estimates of divergence time between the South American populations and their likely sources favor a likely introduction from Africa during the transatlantic slave trade. |
| spellingShingle | Yalcindag, E Elguero, E Arnathau, C Durand, P Akiana, J Anderson, T Aubouy, A Balloux, F Besnard, P Bogreau, H Carnevale, P D'Alessandro, U Fontenille, D Gamboa, D Jombart, T Le Mire, J Leroy, E Maestre, A Mayxay, M Ménard, D Musset, L Newton, P Nkoghé, D Noya, O Ollomo, B Multiple independent introductions of Plasmodium falciparum in South America. |
| title | Multiple independent introductions of Plasmodium falciparum in South America. |
| title_full | Multiple independent introductions of Plasmodium falciparum in South America. |
| title_fullStr | Multiple independent introductions of Plasmodium falciparum in South America. |
| title_full_unstemmed | Multiple independent introductions of Plasmodium falciparum in South America. |
| title_short | Multiple independent introductions of Plasmodium falciparum in South America. |
| title_sort | multiple independent introductions of plasmodium falciparum in south america |
| work_keys_str_mv | AT yalcindage multipleindependentintroductionsofplasmodiumfalciparuminsouthamerica AT elgueroe multipleindependentintroductionsofplasmodiumfalciparuminsouthamerica AT arnathauc multipleindependentintroductionsofplasmodiumfalciparuminsouthamerica AT durandp multipleindependentintroductionsofplasmodiumfalciparuminsouthamerica AT akianaj multipleindependentintroductionsofplasmodiumfalciparuminsouthamerica AT andersont multipleindependentintroductionsofplasmodiumfalciparuminsouthamerica AT aubouya multipleindependentintroductionsofplasmodiumfalciparuminsouthamerica AT ballouxf multipleindependentintroductionsofplasmodiumfalciparuminsouthamerica AT besnardp multipleindependentintroductionsofplasmodiumfalciparuminsouthamerica AT bogreauh multipleindependentintroductionsofplasmodiumfalciparuminsouthamerica AT carnevalep multipleindependentintroductionsofplasmodiumfalciparuminsouthamerica AT dalessandrou multipleindependentintroductionsofplasmodiumfalciparuminsouthamerica AT fontenilled multipleindependentintroductionsofplasmodiumfalciparuminsouthamerica AT gamboad multipleindependentintroductionsofplasmodiumfalciparuminsouthamerica AT jombartt multipleindependentintroductionsofplasmodiumfalciparuminsouthamerica AT lemirej multipleindependentintroductionsofplasmodiumfalciparuminsouthamerica AT leroye multipleindependentintroductionsofplasmodiumfalciparuminsouthamerica AT maestrea multipleindependentintroductionsofplasmodiumfalciparuminsouthamerica AT mayxaym multipleindependentintroductionsofplasmodiumfalciparuminsouthamerica AT menardd multipleindependentintroductionsofplasmodiumfalciparuminsouthamerica AT mussetl multipleindependentintroductionsofplasmodiumfalciparuminsouthamerica AT newtonp multipleindependentintroductionsofplasmodiumfalciparuminsouthamerica AT nkoghed multipleindependentintroductionsofplasmodiumfalciparuminsouthamerica AT noyao multipleindependentintroductionsofplasmodiumfalciparuminsouthamerica AT ollomob multipleindependentintroductionsofplasmodiumfalciparuminsouthamerica |