Rhodium catalysed C-3/5 methylation of pyridines using temporary dearomatisation

Rhodium catalysed C-3/5 methylation of pyridines using temporary dearomatisation

Pyridines are ubiquitous aromatic rings used in organic chemistry and are crucial elements of the drug discovery process. Herein we describe a new catalytic method that directly introduces a methyl group onto the aromatic ring; this new reaction is related to hydrogen borrowing, and is notable for i...

Bibliografske podrobnosti
Main Authors:	Grosavu, A, Hepburn, H, Bailey, E, Lindsay-Scott, P, Donohoe, T
Format:	Journal article
Jezik:	English
Izdano:	Royal Society of Chemistry 2020

Podobne knjige/članki

The reductive C3-functionalisation of pyridinium and quinolinium salts through iridium-catalysed interrupted transfer hydrogenation
od: Grozavu, A, et al.
Izdano: (2018)

New applications of rhodium-catalysed hydroacylation
od: Iwumene, NUN
Izdano: (2022)

A rhodium-catalysed Sonogashira-type coupling exploiting C–S functionalisation: orthogonality with palladium-catalysed variants
od: Arambasic, M, et al.
Izdano: (2019)

New reactivity and selectivity in rhodium-catalysed hydroacylation
od: Pal, R
Izdano: (2020)

Rhodium-catalysed linear-selective alkyne hydroacylation.
od: Poingdestre, S, et al.
Izdano: (2012)

Applications of rhodium-catalysed hydroacylation in heterocycle synthesis
od: Majhail, M
Izdano: (2016)

Rhodium catalysed hydroacylation reactions in the synthesis of heterocycles
od: Ylioja, P
Izdano: (2011)

Mechanistic studies of rhodium-catalysed intermolecular hydroacylation
od: Barwick-Silk, J
Izdano: (2018)

Transition metal free reductive hydroxymethylation of isoquinolines
od: Reeves, B, et al.
Izdano: (2019)

Rhodium-catalysed enantio- and diastereoselective C(sp2)-C(sp3) cross-coupling reactions
od: Goetzke, FW
Izdano: (2021)

Enantioselective rhodium-catalysed insertion of trifluorodiazoethanes into tin hydrides
od: Hyde, S, et al.
Izdano: (2018)

Controlling selectivity in the rhodium-catalysed intermolecular hydroacylation reaction
od: Pawley, R
Izdano: (2012)

Exploring and exploiting selectivity in Rhodium-catalysed hydroacylation reactions
od: Poingdestre, SJ
Izdano: (2012)

Carbon-carbon bond formation via rhodium-catalysed C-S activation processes
od: Arambasic, M
Izdano: (2015)

Dearomatisation of o-xylene by P450BM3 (CYP102A1).
od: Whitehouse, C, et al.
Izdano: (2011)

Asymmetric rhodium catalysed arylation: from ligand design to application
od: Hell, AML
Izdano: (2020)

Development and applications of rhodium-catalysed reactions to explore the synthesis of heterocycles
od: Niu, J
Izdano: (2016)

Studies toward the application and development of rhodium-catalysed hydroacylation reactions
od: Neuhaus, J
Izdano: (2016)

Investigating rhodium-catalysed hydroacylation and carbon-carbon bond activation
od: Coxon, T
Izdano: (2017)

Tandem catalytic processes involving Rhodium-catalysed intermolecular hydroacylation
od: Lenden, P
Izdano: (2011)

The understanding and development of rhodium-catalysed asymmetric cross-coupling reactions
od: Van Dijk, L
Izdano: (2021)

Cationic rhodium complexes with ortho-Aryl substituted DPEphos ligands and rhodium-diphosphine catalysed phosphine-borane dehydropolymerisation
od: Race, JJ
Izdano: (2022)

Rhodium-catalysed regio- and enantioselective Suzuki-Miyaura cross-coupling reactions
od: Liu, K
Izdano: (2023)

Rhodium-catalysed asymmetric allylic arylation of racemic halides with arylboronic acids
od: Sidera, M, et al.
Izdano: (2015)

Rhodium-catalysed vinyl 1,4-conjugate addition coupled with Sharpless Asymmetric Dihydroxylation in the synthesis of the CDE ring fragment of pectenotoxin-4
od: Richardson, M, et al.
Izdano: (2019)

Rhodium-catalysed direct hydroarylation of alkenes and alkynes with phosphines through phosphorous-assisted C−H activation
od: Dingyi Wang, et al.
Izdano: (2019-08-01)

Rhodium-catalysed aryl transfer to aldehydes: counterion effects with nitrogen containing ligands
od: Moreau, C, et al.
Izdano: (2001)

Rhodium-catalysed carbon-carbon bond formation and carbon-sulfur bond functionalisation
od: Bouisseau, A
Izdano: (2017)

Exploiting rhodium-catalysed ynamide hydroacylation as a platform for divergent heterocycle synthesis
od: Straker, R, et al.
Izdano: (2017)

Rhodium-catalysed C(sp2)–C(sp2) bond formation via C–H/C–F activation
od: Tian, Panpan, et al.
Izdano: (2018)

Studies towards the nucleophilic dearomatisation of electron-deficient heteroaromatics and hydrogen borrowing reactions of methanol
od: Poole, DL
Izdano: (2014)

Fused bicyclic piperidines and dihydropyridines by dearomatising cyclisation of the enolates of nicotinyl-substituted esters and ketones
od: Heloise Brice, et al.
Izdano: (2010-03-01)

Asymmetric Suzuki-Miyaura coupling of heterocycles via Rhodium-catalysed allylic arylation of racemates
od: Schäfer, P, et al.
Izdano: (2017)

Rhodium-catalysed hydroacylation or reductive aldol reactions: a ligand dependent switch of reactivity.
od: Osborne, J, et al.
Izdano: (2008)

Rhodium(II)-catalysed tandem aziridination and ring-opening: stereoselective synthesis of functionalised tetrahydrofurans.
od: Unsworth, W, et al.
Izdano: (2014)

Asymmetric Suzuki-Miyaura coupling of heterocycles via Rhodium-catalysed allylic arylation of racemates
od: Philipp Schäfer, et al.
Izdano: (2017-06-01)

Facile generation of bridged medium-sized polycyclic systems by rhodium-catalysed intramolecular (3+2) dipolar cycloadditions
od: Bao-Long Hou, et al.
Izdano: (2021-09-01)

Merging rhodium-catalysed C–H activation and hydroamination in a highly selective [4+2] imine/alkyne annulation
od: Rajith S. Manan, et al.
Izdano: (2016-06-01)

Stereoisomeric Tris-BINOL-Menthol Bulky Monophosphites: Synthesis, Characterisation and Application in Rhodium-Catalysed Hydroformylation
od: Alexandre P. Felgueiras, et al.
Izdano: (2022-03-01)

Machine learnt patterns in rhodium-catalysed asymmetric Michael addition using chiral diene ligands
od: Benjamin Owen, et al.
Izdano: (2022-01-01)