Diabetes and risk of pancreatic cancer: a pooled analysis from the pancreatic cancer cohort consortium.
PURPOSE: Diabetes is a suspected risk factor for pancreatic cancer, but questions remain about whether it is a risk factor or a result of the disease. This study prospectively examined the association between diabetes and the risk of pancreatic adenocarcinoma in pooled data from the NCI pancreatic...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2013
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| _version_ | 1797076295808450560 |
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| author | Elena, J Steplowski, E Yu, K Hartge, P Tobias, G Brotzman, M Chanock, S Stolzenberg-Solomon, R Arslan, A Bueno-de-Mesquita, H Helzlsouer, K Jacobs, E LaCroix, A Petersen, G Zheng, W Albanes, D Allen, N Amundadottir, L Bao, Y Boeing, H Boutron-Ruault, M Buring, J Gaziano, J Giovannucci, E Duell, E |
| author_facet | Elena, J Steplowski, E Yu, K Hartge, P Tobias, G Brotzman, M Chanock, S Stolzenberg-Solomon, R Arslan, A Bueno-de-Mesquita, H Helzlsouer, K Jacobs, E LaCroix, A Petersen, G Zheng, W Albanes, D Allen, N Amundadottir, L Bao, Y Boeing, H Boutron-Ruault, M Buring, J Gaziano, J Giovannucci, E Duell, E |
| author_sort | Elena, J |
| collection | OXFORD |
| description | PURPOSE: Diabetes is a suspected risk factor for pancreatic cancer, but questions remain about whether it is a risk factor or a result of the disease. This study prospectively examined the association between diabetes and the risk of pancreatic adenocarcinoma in pooled data from the NCI pancreatic cancer cohort consortium (PanScan). METHODS: The pooled data included 1,621 pancreatic adenocarcinoma cases and 1,719 matched controls from twelve cohorts using a nested case-control study design. Subjects who were diagnosed with diabetes near the time (<2 years) of pancreatic cancer diagnosis were excluded from all analyses. All analyses were adjusted for age, race, gender, study, alcohol use, smoking, BMI, and family history of pancreatic cancer. RESULTS: Self-reported diabetes was associated with a forty percent increased risk of pancreatic cancer (OR = 1.40, 95 % CI: 1.07, 1.84). The association differed by duration of diabetes; risk was highest for those with a duration of 2-8 years (OR = 1.79, 95 % CI: 1.25, 2.55); there was no association for those with 9+ years of diabetes (OR = 1.02, 95 % CI: 0.68, 1.52). CONCLUSIONS: These findings provide support for a relationship between diabetes and pancreatic cancer risk. The absence of association in those with the longest duration of diabetes may reflect hypoinsulinemia and warrants further investigation. |
| first_indexed | 2024-03-07T00:02:05Z |
| format | Journal article |
| id | oxford-uuid:764957cc-a92a-4a0f-abfe-2bd41db5fab4 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:02:05Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | oxford-uuid:764957cc-a92a-4a0f-abfe-2bd41db5fab42022-03-26T20:14:59ZDiabetes and risk of pancreatic cancer: a pooled analysis from the pancreatic cancer cohort consortium.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:764957cc-a92a-4a0f-abfe-2bd41db5fab4EnglishSymplectic Elements at Oxford2013Elena, JSteplowski, EYu, KHartge, PTobias, GBrotzman, MChanock, SStolzenberg-Solomon, RArslan, ABueno-de-Mesquita, HHelzlsouer, KJacobs, ELaCroix, APetersen, GZheng, WAlbanes, DAllen, NAmundadottir, LBao, YBoeing, HBoutron-Ruault, MBuring, JGaziano, JGiovannucci, EDuell, E PURPOSE: Diabetes is a suspected risk factor for pancreatic cancer, but questions remain about whether it is a risk factor or a result of the disease. This study prospectively examined the association between diabetes and the risk of pancreatic adenocarcinoma in pooled data from the NCI pancreatic cancer cohort consortium (PanScan). METHODS: The pooled data included 1,621 pancreatic adenocarcinoma cases and 1,719 matched controls from twelve cohorts using a nested case-control study design. Subjects who were diagnosed with diabetes near the time (<2 years) of pancreatic cancer diagnosis were excluded from all analyses. All analyses were adjusted for age, race, gender, study, alcohol use, smoking, BMI, and family history of pancreatic cancer. RESULTS: Self-reported diabetes was associated with a forty percent increased risk of pancreatic cancer (OR = 1.40, 95 % CI: 1.07, 1.84). The association differed by duration of diabetes; risk was highest for those with a duration of 2-8 years (OR = 1.79, 95 % CI: 1.25, 2.55); there was no association for those with 9+ years of diabetes (OR = 1.02, 95 % CI: 0.68, 1.52). CONCLUSIONS: These findings provide support for a relationship between diabetes and pancreatic cancer risk. The absence of association in those with the longest duration of diabetes may reflect hypoinsulinemia and warrants further investigation. |
| spellingShingle | Elena, J Steplowski, E Yu, K Hartge, P Tobias, G Brotzman, M Chanock, S Stolzenberg-Solomon, R Arslan, A Bueno-de-Mesquita, H Helzlsouer, K Jacobs, E LaCroix, A Petersen, G Zheng, W Albanes, D Allen, N Amundadottir, L Bao, Y Boeing, H Boutron-Ruault, M Buring, J Gaziano, J Giovannucci, E Duell, E Diabetes and risk of pancreatic cancer: a pooled analysis from the pancreatic cancer cohort consortium. |
| title | Diabetes and risk of pancreatic cancer: a pooled analysis from the pancreatic cancer cohort consortium. |
| title_full | Diabetes and risk of pancreatic cancer: a pooled analysis from the pancreatic cancer cohort consortium. |
| title_fullStr | Diabetes and risk of pancreatic cancer: a pooled analysis from the pancreatic cancer cohort consortium. |
| title_full_unstemmed | Diabetes and risk of pancreatic cancer: a pooled analysis from the pancreatic cancer cohort consortium. |
| title_short | Diabetes and risk of pancreatic cancer: a pooled analysis from the pancreatic cancer cohort consortium. |
| title_sort | diabetes and risk of pancreatic cancer a pooled analysis from the pancreatic cancer cohort consortium |
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