3-D structural and functional characterization of the purified KATP channel complex Kir6.2-SUR1.

3-D structural and functional characterization of the purified KATP channel complex Kir6.2-SUR1.

ATP-sensitive potassium (K(ATP)) channels conduct potassium ions across cell membranes and thereby couple cellular energy metabolism to membrane electrical activity. Here, we report the heterologous expression and purification of a functionally active K(ATP) channel complex composed of pore-forming...

وصف كامل

التفاصيل البيبلوغرافية
المؤلفون الرئيسيون:	Mikhailov, M, Campbell, J, De Wet, H, Shimomura, K, Zadek, B, Collins, R, Sansom, MS, Ford, R, Ashcroft, F
التنسيق:	Journal article
اللغة:	English
منشور في:	2005

مواد مشابهة

Phentolamine block of KATP channels is mediated by Kir6.2.
حسب: Proks, P, وآخرون
منشور في: (1997)

Pyridine nucleotide regulation of the KATP channel Kir6.2/SUR1 expressed in Xenopus oocytes.
حسب: Dabrowski, M, وآخرون
منشور في: (2003)

Involvement of the N-terminus of Kir6.2 in the inhibition of the KATP channel by ATP.
حسب: Proks, P, وآخرون
منشور في: (1999)

Functional analysis of a structural model of the ATP-binding site of the KATP channel Kir6.2 subunit.
حسب: Antcliff, J, وآخرون
منشور في: (2005)

Mapping the architecture of the ATP-binding site of the KATP channel subunit Kir6.2.
حسب: Dabrowski, M, وآخرون
منشور في: (2004)

Glimepiride block of Kir6.2/SUR1 Kir6.2/SUR2A and Kir6.2/SUR2A and Kir6.2/SUR2B K-ATP channels.
حسب: Ashcroft, F, وآخرون
منشور في: (2001)

The Kir6.2-F333I mutation differentially modulates KATP channels composed of SUR1 or SUR2 subunits.
حسب: Tammaro, P, وآخرون
منشور في: (2007)

A mutation in the ATP-binding site of the Kir6.2 subunit of the KATP channel alters coupling with the SUR2A subunit.
حسب: Tammaro, P, وآخرون
منشور في: (2007)

Time-dependent activation of Kir6.2/SUR2A channels but not Kir6.2/SUR1 channels in the presence of ATP
حسب: Ashcroft, F, وآخرون
منشور في: (2001)

Photobiomodulation on KATP Channels of Kir6.2-Transfected HEK-293 Cells
حسب: Fu-qing Zhong, وآخرون
منشور في: (2014-01-01)

Effects of mitiglinide (S 21403) on Kir6.2/SUR1, Kir6.2/SUR2A and Kir6.2/SUR2B types of ATP-sensitive potassium channel.
حسب: Reimann, F, وآخرون
منشور في: (2001)

Time-dependent activation of KIR6.2/SUR2A channels but not KIR6.2/SUR1 channels in the presence of MgATP
حسب: Song, D, وآخرون
منشور في: (2001)

Reduced expression of Kir6.2/SUR2A subunits explains KATP deficiency in K+-depleted rats.
حسب: Tricarico, D, وآخرون
منشور في: (2008)

Dynamic duo: Kir6 and SUR in KATP channel structure and function
حسب: Bruce L. Patton, وآخرون
منشور في: (2024-12-01)

An in-frame deletion in Kir6.2 (KCNJ11) causing neonatal diabetes reveals a site of interaction between Kir6.2 and SUR1.
حسب: Craig, T, وآخرون
منشور في: (2009)

A universally conserved residue in the SUR1 subunit of the KATP channel is essential for translating nucleotide binding at SUR1 into channel opening.
حسب: De Wet, H, وآخرون
منشور في: (2012)

Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic beta cells recapitulates neonatal diabetes.
حسب: Girard, C, وآخرون
منشور في: (2009)

Focus on Kir6.2: a key component of the ATP-sensitive potassium channel.
حسب: Haider, S, وآخرون
منشور في: (2005)

Filter flexibility in a mammalian K channel: models and simulations of Kir6.2 mutants.
حسب: Capener, C, وآخرون
منشور في: (2003)

Structure of an open KATP channel reveals tandem PIP2 binding sites mediating the Kir6.2 and SUR1 regulatory interface
حسب: Camden M. Driggers, وآخرون
منشور في: (2024-03-01)

Kir6.2 mutations causing neonatal diabetes provide new insights into Kir6.2-SUR1 interactions.
حسب: Tammaro, P, وآخرون
منشور في: (2005)

A conserved tryptophan at the membrane-water interface acts as a gatekeeper for Kir6.2/SUR1 channels and causes neonatal diabetes when mutated.
حسب: Männikkö, R, وآخرون
منشور في: (2011)

Identification of residues contributing to the ATP binding site of Kir6.2.
حسب: Trapp, S, وآخرون
منشور في: (2003)

A novel SUR1/Kir6.2 specific K-ATP channel opener
حسب: Dabrowski, M, وآخرون
منشور في: (2001)

The N-terminus of Kir6.2 is involved in coupling to SUR1
حسب: Reimann, F, وآخرون
منشور في: (1999)

Nucleotide modulation of pinacidil stimulation of the cloned K(ATP) channel Kir6.2/SUR2A.
حسب: Gribble, F, وآخرون
منشور في: (2000)

Adjacent mutations in the gating loop of Kir6.2 produce neonatal diabetes and hyperinsulinism.
حسب: Shimomura, K, وآخرون
منشور في: (2009)

Mutations in the genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) in diabetes mellitus and hyperinsulinism.
حسب: Gloyn, A, وآخرون
منشور في: (2006)

The Kir6.2-F333I mutation differentially modulates K-ATP channels composed of SUR1 or SUR2 subunits
حسب: Tammaro, P, وآخرون
منشور في: (2007)

The Kir6.2-F333I mutation differentially modulates K ATP channels composed of SUR1 and SUR2 subunits
حسب: Tammaro, P, وآخرون
منشور في: (2007)

Permanent neonatal diabetes caused by an in-frame deletion in the N-terminus of Kir6.2
حسب: Craig, T, وآخرون
منشور في: (2008)

Screening for mutations in the Kir6.2 subunit of the beta-cell K-ATP channel
حسب: Sakura, H, وآخرون
منشور في: (1996)

Structure-function studies of the fast gating kinetics of the cloned ATP-sensitive potassium channel, Kir6.2/SUR1
حسب: Proks, P, وآخرون
منشور في: (2001)

Behavioral phenotyping of mice lacking the K ATP channel subunit Kir6.2.
حسب: Deacon, R, وآخرون
منشور في: (2006)

Behavioral phenotyping of mice lacking the K ATP channel subunit Kir6.2.
حسب: Deacon, R, وآخرون
منشور في: (2006)

The role of lysine 185 in the kir6.2 subunit of the ATP-sensitive channel in channel inhibition by ATP.
حسب: Reimann, F, وآخرون
منشور في: (1999)

Overlapping distribution of K(ATP) channel-forming Kir6.2 subunit and the sulfonylurea receptor SUR1 in rodent brain.
حسب: Karschin, C, وآخرون
منشور في: (1997)

Interaction of the cytosolic domains of the Kir6.2 subunit of the K(ATP) channel is modulated by sulfonylureas.
حسب: Lippiat, J, وآخرون
منشور في: (2002)

Mapping the architecture of the ATP-binding site of Kir6.2
حسب: Dabrowski, M, وآخرون
منشور في: (2002)

A gating mutation at the internal mouth of the Kir6.2 pore is associated with DEND syndrome.
حسب: Proks, P, وآخرون
منشور في: (2005)