The analgesic effect of epidural clonidine after spinal surgery: a randomized placebo-controlled trial.
BACKGROUND: Clonidine is an alpha(2) adrenoreceptor and imidazoline receptor agonist, which has analgesic, sedative, and minimum alveolar anesthetic concentration-sparing effects. It has been used orally, IV, and epidurally. In spinal surgery, there is a reluctance to use local anesthetic-based epi...
| Autors principals: | , |
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| Format: | Journal article |
| Idioma: | English |
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2009
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| _version_ | 1826279681930821632 |
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| author | Farmery, A Wilson-MacDonald, J |
| author_facet | Farmery, A Wilson-MacDonald, J |
| author_sort | Farmery, A |
| collection | OXFORD |
| description | BACKGROUND: Clonidine is an alpha(2) adrenoreceptor and imidazoline receptor agonist, which has analgesic, sedative, and minimum alveolar anesthetic concentration-sparing effects. It has been used orally, IV, and epidurally. In spinal surgery, there is a reluctance to use local anesthetic-based epidural analgesia postoperatively because of fears of masking important signs of nerve root or spinal cord injury. METHODS: We randomized 66 patients undergoing uncomplicated decompressive spinal surgery to receive an epidural infusion of either clonidine (Group C) or saline placebo (Group P) postoperatively. Morphine consumption by patient-controlled analgesia device was recorded for 36 h. RESULTS: Morphine consumption was significantly lower in Group C. The mean consumption at 36 h was 35 mg (95% confidence interval 21-50 mg) in Group C, compared with 61 mg (95% confidence interval 48-74 mg) in the control group. Nausea was significantly reduced in Group C (6.5%), when compared with placebo (38.2%). CONCLUSION: Low-dose epidural clonidine significantly reduced the demand for morphine and reduced postoperative nausea with few side effects. |
| first_indexed | 2024-03-07T00:02:25Z |
| format | Journal article |
| id | oxford-uuid:7669283b-7844-45fa-8e7b-4acbb517166e |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:02:25Z |
| publishDate | 2009 |
| record_format | dspace |
| spelling | oxford-uuid:7669283b-7844-45fa-8e7b-4acbb517166e2022-03-26T20:15:39ZThe analgesic effect of epidural clonidine after spinal surgery: a randomized placebo-controlled trial.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:7669283b-7844-45fa-8e7b-4acbb517166eEnglishSymplectic Elements at Oxford2009Farmery, AWilson-MacDonald, J BACKGROUND: Clonidine is an alpha(2) adrenoreceptor and imidazoline receptor agonist, which has analgesic, sedative, and minimum alveolar anesthetic concentration-sparing effects. It has been used orally, IV, and epidurally. In spinal surgery, there is a reluctance to use local anesthetic-based epidural analgesia postoperatively because of fears of masking important signs of nerve root or spinal cord injury. METHODS: We randomized 66 patients undergoing uncomplicated decompressive spinal surgery to receive an epidural infusion of either clonidine (Group C) or saline placebo (Group P) postoperatively. Morphine consumption by patient-controlled analgesia device was recorded for 36 h. RESULTS: Morphine consumption was significantly lower in Group C. The mean consumption at 36 h was 35 mg (95% confidence interval 21-50 mg) in Group C, compared with 61 mg (95% confidence interval 48-74 mg) in the control group. Nausea was significantly reduced in Group C (6.5%), when compared with placebo (38.2%). CONCLUSION: Low-dose epidural clonidine significantly reduced the demand for morphine and reduced postoperative nausea with few side effects. |
| spellingShingle | Farmery, A Wilson-MacDonald, J The analgesic effect of epidural clonidine after spinal surgery: a randomized placebo-controlled trial. |
| title | The analgesic effect of epidural clonidine after spinal surgery: a randomized placebo-controlled trial. |
| title_full | The analgesic effect of epidural clonidine after spinal surgery: a randomized placebo-controlled trial. |
| title_fullStr | The analgesic effect of epidural clonidine after spinal surgery: a randomized placebo-controlled trial. |
| title_full_unstemmed | The analgesic effect of epidural clonidine after spinal surgery: a randomized placebo-controlled trial. |
| title_short | The analgesic effect of epidural clonidine after spinal surgery: a randomized placebo-controlled trial. |
| title_sort | analgesic effect of epidural clonidine after spinal surgery a randomized placebo controlled trial |
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