Vaccine-mediated protection of pigs against infection with pandemic H1N1 2009 swine influenza A virus requires a close antigenic match between the vaccine antigen and challenge virus
<p>Swine influenza A virus (SwIV) infection has considerable economic and animal welfare consequences and, because of the zoonotic potential, can also have public health implications. The 2009 pandemic H1N1 ‘swine-origin’ infection is now endemic in both pigs and humans. In Europe, avian-like...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Elsevier
2019
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| _version_ | 1797076345245663232 |
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| author | Everett, H Aramouni, M Coward, V Ramsay, A Kelly, M Morgan, S Tchilian, E Canini, L Woolhouse, M Gilbert, S Charleston, B Brown, I Brookes, S |
| author_facet | Everett, H Aramouni, M Coward, V Ramsay, A Kelly, M Morgan, S Tchilian, E Canini, L Woolhouse, M Gilbert, S Charleston, B Brown, I Brookes, S |
| author_sort | Everett, H |
| collection | OXFORD |
| description | <p>Swine influenza A virus (SwIV) infection has considerable economic and animal welfare consequences and, because of the zoonotic potential, can also have public health implications. The 2009 pandemic H1N1 ‘swine-origin’ infection is now endemic in both pigs and humans. In Europe, avian-like H1<sub>av</sub>N1, human-like H1<sub>hu</sub>N2, human-like swine H3N2 and, since 2009, pandemic H1N1 (pH1N1) lineage viruses and reassortants, constitute the dominant subtypes. In this study, we used a swine pH1N1 challenge virus to investigate the efficacy of whole inactivated virus vaccines homologous or heterologous to the challenge virus as well as a commercial vaccine. We found that vaccine-mediated protection was most effective when vaccine antigen and challenge virus were homologous and correlated with the specific production of neutralising antibodies and a cellular response to the challenge virus. We conclude that a conventional whole inactivated SwIV vaccine must be antigenically matched to the challenge strain to be an effective control measure.</p> |
| first_indexed | 2024-03-07T00:02:44Z |
| format | Journal article |
| id | oxford-uuid:7686a443-c0a9-4322-9256-fab0db5c966a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:02:44Z |
| publishDate | 2019 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:7686a443-c0a9-4322-9256-fab0db5c966a2022-03-26T20:16:53ZVaccine-mediated protection of pigs against infection with pandemic H1N1 2009 swine influenza A virus requires a close antigenic match between the vaccine antigen and challenge virusJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:7686a443-c0a9-4322-9256-fab0db5c966aEnglishSymplectic Elements at OxfordElsevier2019Everett, HAramouni, MCoward, VRamsay, AKelly, MMorgan, STchilian, ECanini, LWoolhouse, MGilbert, SCharleston, BBrown, IBrookes, S<p>Swine influenza A virus (SwIV) infection has considerable economic and animal welfare consequences and, because of the zoonotic potential, can also have public health implications. The 2009 pandemic H1N1 ‘swine-origin’ infection is now endemic in both pigs and humans. In Europe, avian-like H1<sub>av</sub>N1, human-like H1<sub>hu</sub>N2, human-like swine H3N2 and, since 2009, pandemic H1N1 (pH1N1) lineage viruses and reassortants, constitute the dominant subtypes. In this study, we used a swine pH1N1 challenge virus to investigate the efficacy of whole inactivated virus vaccines homologous or heterologous to the challenge virus as well as a commercial vaccine. We found that vaccine-mediated protection was most effective when vaccine antigen and challenge virus were homologous and correlated with the specific production of neutralising antibodies and a cellular response to the challenge virus. We conclude that a conventional whole inactivated SwIV vaccine must be antigenically matched to the challenge strain to be an effective control measure.</p> |
| spellingShingle | Everett, H Aramouni, M Coward, V Ramsay, A Kelly, M Morgan, S Tchilian, E Canini, L Woolhouse, M Gilbert, S Charleston, B Brown, I Brookes, S Vaccine-mediated protection of pigs against infection with pandemic H1N1 2009 swine influenza A virus requires a close antigenic match between the vaccine antigen and challenge virus |
| title | Vaccine-mediated protection of pigs against infection with pandemic H1N1 2009 swine influenza A virus requires a close antigenic match between the vaccine antigen and challenge virus |
| title_full | Vaccine-mediated protection of pigs against infection with pandemic H1N1 2009 swine influenza A virus requires a close antigenic match between the vaccine antigen and challenge virus |
| title_fullStr | Vaccine-mediated protection of pigs against infection with pandemic H1N1 2009 swine influenza A virus requires a close antigenic match between the vaccine antigen and challenge virus |
| title_full_unstemmed | Vaccine-mediated protection of pigs against infection with pandemic H1N1 2009 swine influenza A virus requires a close antigenic match between the vaccine antigen and challenge virus |
| title_short | Vaccine-mediated protection of pigs against infection with pandemic H1N1 2009 swine influenza A virus requires a close antigenic match between the vaccine antigen and challenge virus |
| title_sort | vaccine mediated protection of pigs against infection with pandemic h1n1 2009 swine influenza a virus requires a close antigenic match between the vaccine antigen and challenge virus |
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